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Author Topic: Poss progesterone allergy?  (Read 203 times)

Mishmash1982

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Poss progesterone allergy?
« on: November 05, 2025, 05:07:41 PM »

Im going to start from the beginning so all the info is here as i really feel like i need some help.
I start on everol conti 50 2.5 yrs ago, no issues until about 18 months ago, started new relationship amd constant UTIs and BV, trying to tackle that and the GP increased to everol 75 in march, things were great and no issue, increase again too 100 from sept along with oral progesterone to top up the progesterone that i have in Depo inject, within a week of taking i had theeee most uncomfortable vagina, dry, sore, itchy, cut, treated for BV and thrush nothing helped until i read online the adverse effects of progesterone....in mean time gp says cant stay on Depo amd not enough progesterone for the 100mg patch so need coil, had that fitted within a week the sore vagina was back, i was applying KYjelly 100x a day or thats how it felt ...straight on phone to gp who prescribed 1x vagifem per day but it wasnt helping much so i upped it tp 2x a day and with 24hrs it felt better but still round the urethra was very itchy/stabby sensation...she then prescribed me estroil which has taken symptoms down by about 75% but have to apply probably every 2 hrs.
So i know this is a side effect of the progesterone in the mirena coil any ideas if it will settle?
Is it a case of body adjusting or should i just say i want the coil out asap

Any advice at all would be amazing??
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CLKD

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Re: Poss progesterone allergy?
« Reply #1 on: November 05, 2025, 05:18:46 PM »

From where I'm sitting your GP is being very slow about diagnosis: vaginal atrophy certainly springs to mind ; it mimics repeated urine infection-type symptoms really really well.

 The idea is to use VA treatment every night for 2-3 weeks, then as required.  Some find that they are OK with every 3rd and 5/6th nights for example, others require it nightly.  I use estriol internally via an applicator as well as smearing a little around the labia and vulva which helps counteract any dryness = irritation/itchyness.

There are products i.e. Yes and Sylc, moisturisers to use around the labia etc. as well as vagifem.  It may take a while to get relief from symptoms so it's important not to miss. When mine niggle I add an 'extra' estriol mid afternoon, swallow 2 Nurofen and continue treatment for 3-5 nights.

Some ladies require replacement therapies along side appropriate VA treatment.  As oestrogen levels drop the body may become dry inside and out: scalp, skin, deep in the ears, nostrils, vagina ....... and muscles may become lax = aches and pains. 

There is also a condition known as 'honeymoon cystitis'  ::)

If a lady has her womb she requires progesterone with oestrogen replacement unless she opts for a longer cycle of oestrogen without as much progesterone in which case regular womb scans are recommended.  I suggest giving the Mirena at least 3-4 months along side keeping up with VA treatment.

Would keeping a mood/food/syptom diary help at all?



Im going to start from the beginning so all the info is here as i really feel like i need some help.

I start on everol conti 50 2.5 yrs ago, no issues until about 18 months ago, started new relationship amd constant UTIs and BV, trying to tackle that and the GP increased to everol 75 in march, things were great and no issue, increase again too 100 from sept along with oral progesterone to top up the progesterone that i have in Depo inject, within a week of taking i had theeee most uncomfortable vagina, dry, sore, itchy, cut,

treated for BV and thrush nothing helped until i read online the adverse effects of progesterone....in mean time gp says cant stay on Depo amd not enough progesterone for the 100mg patch so need coil,

had that fitted within a week the sore vagina was back, i was applying KYjelly 100x a day or thats how it felt ...straight on phone to gp who prescribed 1x vagifem per day but it wasnt helping much so i upped it tp 2x a day and with 24hrs it felt better but still round the urethra was very itchy/stabby sensation...she then prescribed me estroil which has taken symptoms down by about 75% but have to apply probably every 2 hrs.

So i know this is a side effect of the progesterone in the mirena coil any ideas if it will settle?

Is it a case of body adjusting or should i just say i want the coil out asap

Any advice at all would be amazing??
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Ayesha

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Re: Poss progesterone allergy?
« Reply #2 on: November 05, 2025, 05:27:38 PM »

Topical oestrogen can take four months to take affect, give it time with constant use and hopefully you will feel the results, just needs patience.
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bombsh3ll

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Re: Poss progesterone allergy?
« Reply #3 on: November 05, 2025, 05:30:57 PM »

If you tolerate the depot provera injection but not the micronised progesterone, why not just ask for oral provera as your progestin?

This is medroxyprogesterone acetate, a 5mg tablet daily is typically used for endometrial protection.

This is its licenced indication and it is most well known from the WHI.

Whilst no longer first line it is still a very safe and effective treatment with robust safety data.
« Last Edit: November 05, 2025, 06:28:58 PM by bombsh3ll »
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Mishmash1982

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Re: Poss progesterone allergy?
« Reply #4 on: November 05, 2025, 06:19:52 PM »

Hi, im just not good with tablet and remembering to take them, hence the depo since falling pregnant at 18yrs old...im 43 now so dont fancy a baby at my age lol
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Mishmash1982

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Re: Poss progesterone allergy?
« Reply #5 on: November 05, 2025, 06:23:56 PM »

CLKD
gp very slow. I have an app monday but contacted them last week asking for vagifem and estroil as i had picked up a lot of info from here and desperatly needed something to try until i got the appointment.

Im also wondering if i need my patch increasing to 125

Im also battling BV which atm is ok as no sex but once that comes im using lactic acid pesseries up there also. Im just so fed up and have cried 2 days straight
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Mishmash1982

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Re: Poss progesterone allergy?
« Reply #6 on: November 05, 2025, 06:55:28 PM »

Topical oestrogen can take four months to take affect, give it time with constant use and hopefully you will feel the results, just needs patience.

Thank you!!
Silly question but is this likly to be a lifetime thing?
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CLKD

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Re: Poss progesterone allergy?
« Reply #7 on: November 05, 2025, 07:35:56 PM »

Yep.  For many regular treatment to keep symptoms under control may be necessary for ever.

Personally my symptoms have improved with treatment so that I can go many months between requiring estriol.  I recognise the warning niggles.

Nowt is silly or stupid on this Forum - if people don't ask questions they don't get answers ;-)
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Ayesha

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Re: Poss progesterone allergy?
« Reply #8 on: November 05, 2025, 07:53:13 PM »

Vaginal Atrophy treatment is for life, my regime is Vagifem seven days plus Estriol smeared on the outside twice a day. If I decrease the dose by one day my symptoms quickly return, I am not on systemic HRT,  relying purely on topical treatment.

The document in the link explains in great detail all the symptoms and treatments for GSM
https://bssm.org.uk/wp-content/uploads/2023/02/GSM-BSSM.pdf
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Mishmash1982

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Re: Poss progesterone allergy?
« Reply #9 on: November 05, 2025, 08:20:32 PM »

Yep.  For many regular treatment to keep symptoms under control may be necessary for ever.

Personally my symptoms have improved with treatment so that I can go many months between requiring estriol.  I recognise the warning niggles.

Nowt is silly or stupid on this Forum - if people don't ask questions they don't get answers ;-)

Thank you!!
Im 101% sure this is liked to the mirena coil as the exact same happened when i was take the prog orally...im happy to give it a few months to see if it settles and my body gets used to it but if not i think ill have to have the coil removed and have a look at other options
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