Hi lovesflorida - I'm afraid it is a trial and error process when it comes to finding the right HRT. What long term side effects are you worried about? Don't believe all the negative stuff in the press. The long term benefits can be great e.g. 5 years of HRT can protect you heart and bones for the long term.
Most HRTs have bio identical oestrogen these days (so no equine hormones) and many progesterones are simply synthetic so not derived from animals. There is a bio identical progesterone called Utrogestan which is becoming very popular.
Do look under TREATMENTS on this site to get clued up - print stuff off to show your GP as this will help with your decision about what to choose. I would suggest you don't use a continuous HRT to start with, even if you are post menopause, as it's better to try a sequential HRT so you can tell if the progesterone suits you or not. You can move to a continuous HRt after 3-6 months if you find the progesterone is OK.
I found Utrogestan very problematic in terms of side effects while many women love it. If you want to try HRT pills then Femston 1/10 would be a good start as this has a gentler progesterone that suits many women very well. If you want to go transdermal, then you could have the combined patches (these come as sequi and conic) OR, better still, have oestrogen as patches or gel and then use either Utrogestan or Provera as the progesterone part of a regime.
If you are just suffering with low mood and anxiety, I must warn you that these meno symptoms are the toughest to treat and it can take time for HRT to work. You will need to use a range of strategies that involve not just HRt but also changes in diet, exercise and relaxation techniques to really feel the full benefit of HRT.
If you have flushes and night sweats, then these can be helped quite quickly with HRT, so you can start to feel better within 2-3 months.
Your GP will probably offer Elleste, which has a harsher progesterone, so I would push for Femoston 1/10 first as he/she is more likely to prescribe this. GPs are seldom familiar with Utrogestan so it can be a struggle to get them to let you try this. It's often a matter of leading GPs gently toward the various options and if need be ask fi there is a meno clinician near you fro more specialist advice. Good luck DG x