I hope this explains a bit better

Thank you for coming to see me for an integrated approach to your probable 23 year effects of post-partum depression(PPD).
PPD is a highly complex issue as there are many theories behind why it happens. You have been treated, by Prof Studd, on the basis of either oestrogen or progesterone being of benefit, but this has had only short term and limited benefits, probably associated with oestrogens.
You have been tried on Escitalopram, a selective serotonin re-uptake inhibiter (SSRIs) and Lamotrigine with what you describe as a '5/10' benefit.
I explained to you my theory that oestrogen and progesterone receptors increase in number through pregnancy due to the high level of these hormones. In some women, when these hormones diminish after delivery, the receptors do not reduce in number and the individual starts to 'crave' the hormones. In a sense, this is a form of addiction and leads to depression, loss of motivation, anxiety and then onto physical symptoms.
There is a clear link between PPD and thyroid dysfunction.
http://www.postpartumprogress.com/thyroid-problems-in-women-postpartum-depression. A lot of your symptoms are similar to hypothyroidism but then they are also similar to oestrogen dominance
http://www.postpartumprogress.com/thyroid-problems-in-women-postpartum-depression.
I also explained how prolonged stress requires a lot of cortisol (the bodies stress coping hormone) and I showed you the attached steroidogenic pathway chart which explains how progesterone levels drop if cortisol has to be made in abundance. When stressed the brain tries to make more calming hormones. These neurotransmitters are very dependent upon nutrition, particularly, amino acids, vitamins B complex, magnesium, zinc, iron and vitamin D.
I am highly suspicious that your long-term lack of fruit and vegetables (I do not think you are getting anywhere near your 9 or 10 portions a day) would have led to nutritional deficiency, which has not allowed your body to make its own 'happy hormones'. Artificial sugars trick the body into thinking it has energy and when it finds
no sugar there the body's biochemistry goes wrong. Adrenalin is produced to put sugar into the blood stream and this adds to the anxiety.
Recommended Treatment
There are no specific treatments that reduce oestrogen and progesterone receptors, or specific treatment that can sensitise the body cells to thyroxine. Detoxification might help as that may clear receptors.
We can, however, increase thyroid activity, so effectively increasing T4 and T3 levels, and we can encourage the body to make more of its calming hormones. By doing this we reduce the adrenaline affect which, in turn, reduces the demand for cortisol and so the stress response diminishes, the progesterone levels return, hopefully, to normal and the oestrogen dominance goes away.
To help this I suggest you take the following supplements:
Pregnenolone – a hormone made by the body which helps balance oestrogen and progesterone.
Thyro-complex
T-Convert
Pro Dial Vit 44 - a multi nutrient to replenish deficiencies
HPA- JA is an adaptogen. Adaptogens are nontoxic substances, generally from plants, that increase the body's ability to resist the damaging effects of stress and promote or restore normal physiological functioning. Please see the attached.
I would like to see how you get on over 1 month. If you are not improving then I will move to natural plant oestrogens or bioidentical hormones and increase the strength of the supplements and also consider a short trial on natural thyroxine. Lots of avenues for us to travel down.
Nutritionist
I think it extremely important that you sit with a nutritionist. We have to create a plan for you that you will stick to. Nutritionists will take the time to establish what it is that you like and don't like in food and help you design a plan that you will find easy to stick to over the years. Without good nutrition there is reduced chance of you rebalancing your neurotransmitters and hormones.