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Author Topic: utrogestan/estrogel support group  (Read 974705 times)

Hurdity

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Re: utrogestan/estrogel support group
« Reply #1545 on: March 29, 2019, 07:17:34 PM »

😁😁 me too. 1 pump = .75mg, as it says on the back of the bottle but notice it says 0.06% as well. The actual amount of hormone is 0.06% of that.
The patch has 3.3mg of oestrogen in it but delivers 50micrograms over 24 hours.
The gel has hormone suspended in it at 0.06%.
So, now I think that means 1 pump of gel is equal (ish) to the amount you get in an Evorel Conti patch over 24 hours.
I failed maths but Richard didn't and he's smart.

Hi Birdy

Just to clarify re the maths of the gel and what it contains. The 0.06 % refers to the quantity of the active ingredient (in this case) estradiol in a given amount of gel - so 1 g gel (= 1000 mg) contains 60 mg estradiol. One pump of oestrogel comprises 1.25 gel (=1250 mg), so 0.06 % of that is 75 mg.  The bottle is telling you how much estradiol each pump of the gel contains.

I can't see over the page now I've started posting but I think the questions were about comparison between patch and gel? I think it's already been said that the patch doses are given as the amount delivered over a 24 hour period driectly into the bloodstream (measured in micrograms: 1000 mcg - 1 mg) - and it doesn't all get used up. I presume it needs to be that amount to ensure that dose fairly consistanetly over the period of time it's stuck on. I might do a separate post about this as it often comes up and is very confusing!!  ::).

A lot of the gel doesn't get absorbed because it dries before this happens and also will depend on your type of skin, produicts used etc. Again the doses will have been worked out to give the measured systemic estradiol levels on average for a given dose.

Does that clarify a bit?

As already said - best to go by symptoms and low medium and high doses but it does seem some women fall into the extremes of the different amounts absorbed.

Hurdity x
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itsmejojo

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Re: utrogestan/estrogel support group
« Reply #1546 on: April 01, 2019, 08:19:16 PM »

Hi

I'm new to the MM forum and spent most of last night scrolling through the thread.

I'm 47 and been in perimenopause for about 5 years, attempting to manage with the usual ‘alternative' stuff but the last 6 months have been horrible. I had to give up my job last November, 3 hours of commuting everyday had become impossible and the brain fog/recall had become embarrassing.  I worked in a male dominated business and there was no understanding or consideration for my situation.

A history of thrombosis, TIA's and stroke in my family had put me off HRT for a long time but symptoms have just got too much…night sweats, insomnia, fatigue, joint pain (hips, lower back and hands), brain fog, recall, weight gain etc, etc.

I read a lot of information and saw my GP a few times to discuss options before finally deciding, she advised the oestrogen patch and Mirena coil was the best route. I was reluctant to have the Mirena as I'd had a bad experience with it in the past.

I found the Easy HRT prescribing guide on the PCWHF and took it back to my GP.  She was happy to listen and asked for a copy of the guide to share with her colleagues!  She prescribed Estrogel and Utrogestan and told me to start taking it immediately.
 
On 1st March I started on 2 pumps (1 morning and 1 night) and 200mg (2 x 100mg capsules) Utrogestan orally at night.  I am still having periods, but they aren't regular and on day 3 I had the first one in 11 weeks.
 
I felt anxious, emotional and irritable all the time which weren't issues pre HRT, I had a phone appointment with my GP and she advised increasing to 4 pumps of gel per day and to stick with it, everything will settle down.  On 4 pumps I felt much worse than before, so I made the decision to stop everything last week.
 
I promptly went online and spent a small fortune on a whole new batch of alternatives including CBD but I can't help feeling that if I'd had some proper advice and support I could have persevered and found a level that worked.

After reading the thread last night I have learned so much.  The knowledge and dedication of some members is amazing and reading about those of you who have had success with HRT and made huge improvements in your quality of life, it's given me renewed hope and I want to try again. 

But, I have so many questions and I know my GP won't have the answers...

•   Are 4 pumps too much?
•   Should I have waited until day 16 to start taking the Utrogestan?
•   Was Utrogestan responsible for causing the mess I was in emotionally?
•   Should I try Utrogestan vaginally?  Maybe I'm sensitive to it?
•   Utrogestan day 1-25, or for 12 days from day 16-28 or for 12 days every 2 months?
•   Gel on arms or legs?
•   Patches vs gel?

I'd be so grateful for any advice.

Thanks!

X
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Ladybt28

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Re: utrogestan/estrogel support group
« Reply #1547 on: April 01, 2019, 11:54:32 PM »

hey itsmejojo,
So loads of questions... I will do my best to answer from my own experiences but firstly  :welcomemm:  for me this forum  has been a lifeline and I know it is for others as well.  I have also found more info and experience here than I have ever found in the medical world and I trust what I learn here implicitly.

I will try to go down in order...So convential wisdom here and in the medical profession who have a bit of a clue what they are talking about (they do exist but are few and far between) say that it takes 3 months for an hrt regime to settle.  It is not a quick process and you will get all sorts of things happening when you first start out - loads of things you won't have been told about and loads of things which are just unique to you and your own body and then things which most of us have here have experienced at one point or another.

Therefore in answer to your question - you did give up too early - perseverance is the key to start - 1 month is not even enough for your body to adjust.  The mess you were in emotionally was because your body needed to adjust to the extra hormones - I would have put money on it that it was likely to settle if you persevered.  I would not have suggested to go to 4 pumps after such a short period of time,  but have stayed at 2 for at least 6 weeks before upping it one pump at a time every 3 weeks.  It takes a while for the oestrogen levels to come up in the body - not a quick fix.  It took me a whole 7 months to get rid of ALL the symptoms you describe for going onto hrt plus anxiety and irritability and panic attacks and agrophobia which WERE part of my menopause.  It can work quicker for some but most of us it is more of the long haul!

Item 2 - perimenopause makes it extremely difficult to get the types of hormones and the regime to balance and it depends a what stage you are in it and what age as to how that goes.  Your body is including your own hormones with those you are putting into it and those hormones will have their say as you go along.

In terms of starting your regime gell and utrogestan - gps like to start you on 1st of the month because it makes it easier to count and keep track of what happens on what days.  It depends on what regime you want to do is when you take your Utrogestan.  You can take it continuously and try to balance it against the gel the ideal being that you wont get bleed - usually more for post meno women because they dont have their own cycle like you do in peri which interferes with the balance.  Remember you have your own cycle and hormones still which will interact with what ever level of hrt you put into your body.
This cycle/regime is a "continuous" regime and the aim is to control the bleed to a little as possible.

Option 2 if a "cycle or conti" regime where you introduce the utrogestan for a certain number of days and it effectively tricks your body into the cycle you want and the bleed happens when you want.  Well that the theory anyway.  I am 57 post meno and still do a cycle because I want bleed (reasons later as the answer to one of your questions).  It is likely as you mention day 16 to start utrogestan that you would be going for 12 days at 200mg utrogestan and then a bleed cycle. So yes day 15 is actually the day.  When you stop after 13/14 days (varies) then you may go a couple of days and bleed for  3/4/or 5 - depends.

Answer 4 - I have to use Utro vaginally - I am one of those women who is fairly sensitive to it. It can be taken orally and you may be able to tolerate it but until you try no one can say and you wont know.  When taken orally its potency is diminished by going through the stomach and some women have problems because it needs to be processed by the liver.  Your choice - depends how you react - trial and error again.

The reason why you bleed is your own cycle kicked in over the hrt because you hadn't had your hrt long enough to overide your own cycle and get a balance.

The level of gel for you depends on your body and is trial and error.  One of the reasons women like separate oestrogen and progesterone is that they can play around with the levels themselves without having to go to the GP and get different doses of patches or pills prescribed when they need to go up or down.
So answer to question 1 - gps start at 2 pumps - I use 4 pumps for me and I do know a few women who need up to 6, thefore - "how much is too much" - the answer is "when it feels right for you and your symptoms are under control".  I use my gell on my arms and legs alternately.  Some women don't like to put it on the inner arms, they think it is too close to the boobs.  I don't have a problem with either and bear in mind 4 pumps is a lot of gel!

Think that just about covers it for now - but I would definitely give it another go now you know more what to expect and the timeline.  Keep posting and there will be loads of people here to answer your questions as you go along.  There are no daft or stupid questions so ask away.  Tell us all about what you are experincing and how you are feeling - there is nothing you could tell us about that someone on the forum doesnt know something about.
Ladybt28 xx





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itsmejojo

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Re: utrogestan/estrogel support group
« Reply #1548 on: April 02, 2019, 12:06:37 PM »

Thank you Ladybt28 and Stellajane really appreciate you taking the time to respond.

I'm giving it another go, starting first with 2 pumps of gel for a few weeks and then start Utrogestan day 15 vaginally.  I'm having some cramps and a bit of spotting today so think another bleed is coming, would you advise waiting to get this out of the way before I start HRT again?

The issue with previous Mirena was about 15 years ago.  I was bleeding for weeks after it was put in, I was sent for a scan to check it was in the correct position which it was and told the bleeding would eventually stop.  A few weeks later still bleeding I had cramps on par with labour pains, I went to A&E and it was stuck in my cervix so had it removed, don't want to risk that again.

Thanks! X
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Hopeful1

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Re: utrogestan/estrogel support group
« Reply #1549 on: April 03, 2019, 10:24:13 AM »

Hi can i just check if people are increasing their estrogel dose to help with physical symptoms like hot flashes returning or can increasing the dose help with emotional symptoms like mood swings too?
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Ladybt28

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Re: utrogestan/estrogel support group
« Reply #1550 on: April 03, 2019, 02:20:56 PM »

Increasing my dose of gel helped with the flushes and stopped my anxiety and panic attacks, but that is my personal experience. It doesn't always stop the anxiety or mood swings.  You can only try and wait long enough for it to settle.  Sometimes when you increase the dose those appear to get worse until the body balances itself out.  It really is trial and error Hopeful1 with a huge helping of patience.
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Hopeful1

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Re: utrogestan/estrogel support group
« Reply #1551 on: April 03, 2019, 03:52:17 PM »

Thanks ladybt for the reminder about patience. I need a truck load.
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Ladybt28

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Re: utrogestan/estrogel support group
« Reply #1552 on: April 03, 2019, 05:30:40 PM »

See the fogginess Birdy - mine went for the first time in 20 years when they gave me Testosterone. brain and thought process more sharp. The only symptom out of the...what is it..20 you can have on the list?  I am left with is crippling depression.  All the rest have gone, which is a flaming miracle.  When I had them all they were all "loud" but now they have all gone, the depression this dark cloud is huge.  I'm not foggy anymore, when I do have a thought it's sharp just it feels like someone has taken the whole of my brain out of my head and so nothing is connected to my body.  It's very weird.
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Ladybt28

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Re: utrogestan/estrogel support group
« Reply #1553 on: April 03, 2019, 07:28:21 PM »

Yep I had pregnanalone before but I got it from America through that book I wrote about in posts before called The Mood Cure but it didn't work for me then.  I think my body had too many different problems to fix all in one go at the time.

Sludge is a good word Birdy...been there I know what that feels like.  Wish I could make it better but I need to take my own advice and make me better than I am right now.
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Tracey E

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Re: utrogestan/estrogel support group
« Reply #1554 on: April 06, 2019, 04:00:51 PM »

Hi, I've been on this combination of HRT for fifteen days now.  One pump and a bit of Estrogel and one 100mg of Utrogestan per day. Day 15 and my boobs have expanded and feel very tender is this normal?
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Tracey E

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Re: utrogestan/estrogel support group
« Reply #1555 on: April 06, 2019, 06:52:04 PM »

Birdy, do you think I may be using too much Estrogel or is it more likely the Utrogestan causing the excessive tenderness?  ::)
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Tracey E

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Re: utrogestan/estrogel support group
« Reply #1556 on: April 06, 2019, 10:40:13 PM »

One and a half pumps is a fairly low dose. Two is standard I believe. I think it's the sudden surge of oestrogen that's affected your boobs. Mine became quite tender and up a cup size and my meno nurse said it was oestrogen. But who knows? I would wait it out. Fifteen days isn't much time at all x

Did yours get less tender with time then? x
« Last Edit: April 06, 2019, 10:48:16 PM by Tracey E »
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Ladybt28

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Re: utrogestan/estrogel support group
« Reply #1557 on: April 06, 2019, 11:40:46 PM »

Mine were quite sore for about the first month or maybe more, bit difficult to remember Tracey, but then it settled down.  I don't think it is too much as birdy says, its your body settling down.  15 days is a very short period of time.
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Sparkler

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Re: utrogestan/estrogel support group
« Reply #1558 on: April 10, 2019, 04:33:13 PM »

Hi Ladies. This is an amazing forum and I am in awe of everyone's experience. I hope you can answer my question.

I am in my first month of Evorel 25 and Utrogestan 200mg orally for 12 days. All good so far, a little shaky the first couple of days on evorel then it settled. Also fine on the Utrogestan, currently on day 7, but I have a question.

I took the utrogestan about an hour before bed, which was a longer gap than usual. Other nights it had only been 10 mins between taking i5 and bedtime . By the time I was climbing the stairs I was so dizzy that both me and DH were quite worried. I was falling over dizzy!

This morning though, I woke up fine as usual, not even groggy at 6am and got on with the day.

Is this a worry? It was, undoubtedly, scary!

Sparkler
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Hurdity

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Re: utrogestan/estrogel support group
« Reply #1559 on: April 10, 2019, 06:56:28 PM »

Yes Sparkler, judging by the pharmacokinetic info (how the hormones is metabolised in the body over time ie the time course of the active ingredient) on the web, peak serum (blood) levels of progesterone can be obtained very quickly after oral intake so this is likely to be the cause of your dizziness. Even though I use it vaginally and at night, I still sometimes go through mild dizzy patches during the day when I'm on the prog phase, which disappear once I'm back to the oestrogen only.

Great news that you were feeling normal by morning though. Personally I would not be worried but if it happens when you are not on the prog phase and/or at other times of the day, then do go to your doc and get checked out - or if you are worried. You could take it vaginally to minimise the dizzy spells but you might not want to do this for 12 days per month.

I hope it all settles down for you.

Hurdity x
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