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[Vicky81]

Hi
I've had bad fluctuations (unknown to me) while taking yasmin as the SHGB took a hold if it and stopped it from working as yhe estrogen was too much So it got binded.
GP agreed last night.
I've had bad anger ....just like in 21 when my peri started ...smashing stuff hitting radiators cowering shivering in ghe corner of the bedroom it was bad ....Dr's near knew it was peri ....they nearly took me away seriously it was embarrassing as I work in this field.
So these fluctuations have come back to haunt me and I can't take it any more. Yesterday again anger .  No one in the flat just me throwing cushions , punched the set of drawers, then the crying comes ....exactly the same as 21 even GP said you're fluctuating.
So I'm day 3 today of my pill break bleed and boy have I shed already ...
So my question....primarily to Bombsh3ll if that's OK....and everyone too.- how soon can I start this Slynd ..  .I'm getting desperate can't go out or anything .....I usually leave yye bleed til about day 7 then back to yasmin but this time it's been alot worse.....alot worse! I was going to give it til noon ish today see if the blood has gone down/ not alot there and start today what do you think,?
I shed alot last night (sprry) a big piece ws at the bottom of the loo no wonder I had pains lol.....please please help as they want me back at work on 22nd which is next Wed I know things don't work straight away but I'm desperate.  Please help I'm at yhe end of my rope and not coping with my terrible presentation....love u all xxx vic xxx
 

[bombsh3ll]

Just start it now, there is nothing to gain by waiting.

It is unlikely to stop the bleeding straight away but it should lighten and tail off over the coming days.

It might take a few weeks but if you take the slynd consistently every day with no breaks, most women are bleed free after the first few months, and those who aren't generally only have light occasional bleeding or spotting.

[Vicky81]

Ahhhh bombsh3ll I was hoping you'd come through!
I've just had a questions and answers with a obs gynae who agreed you can start today or we say between days 1-5 of your bleed is OK....I asked if ny patch woukd raise this SHGB he saud no cos the patch bypasses the liver. He explained that the fake estrogen in the combined pill goes through the liver and over stimulates it creating alot of SHGB which can then bind it....that's what's happened to me he said .
He said 7-14 days to suppress, and about 2-6 weeks for my mood and energy to take a shift . Xxxx

[Vicky81]

Just start it now, there is nothing to gain by waiting.

It is unlikely to stop the bleeding straight away but it should lighten and tail off over the coming days.

It might take a few weeks but if you take the slynd consistently every day with no breaks, most women are bleed free after the first few months, and those who aren't generally only have light occasional bleeding or spotting.

Bomb I'm gunna give this slynd a go but by hiw many weeks woukd you know it was giving yiu fatigue?
It coukd just be me but I've had bad fatigue fir weeks and weeks nit knowing what's causing it ....every blood test lots of mri scans....now it could have been this SHGB going up and up without me knowing obviously.....so I got more fatigue when I took the provera fir 3 days, they sent me home from work, then when bleed came even more fatigue I was crying with it. Today is dsyc3 I'm still bleeding but not heavy as I took Slynd at 10.35 this morning. 
I'm soooo fatigued can't tell u. My partner says it's cos I've halted d the bleed and my hormones must be evershere cos the synd is trying to suppress .
What's your thoughts please? As I don't want a pill making me more fatigued that I have been..
.if hts the case it is the Slynd how long wpuod you know? 2 weeks? Cis I have work yo think of too.
And what woukd be a good second in line? Cerazette? Hope yiu don't think I'm jumping the gun but I've been suffering fatigue ages now nut it's not chronic fatigue syndrome I've asked plenty of Dr's. I took b12 injections 4 .months ago which rocked my nervous sytem and gave me fatigue which it did last time i tried it in tablet form, the withdrawal site im on always tells ppl to go in very low with b12 and i didnt they were so right ...last time I got yhe numbers checked 2 week ago it was still high ....high fir someone in withdrawal. 
So it could be thst . I don't know . But this afternoon I've felt so awfully fatigued I'm sat up in bed.
Just need your thoughts and advice please 🙏

[dangermouse]

When I have ever taken progesterone/progestins they make me feel worse for about 3 days as they are displacing oestrogen from the tissues. Once that passed through the bowels, there was an immediate sense of relief.

Definitely keep at it for a few days at least.

[Vicky81]

Awwww danger mouse thank you so much for replying xx
I got really worried  earlier thinking oh God I hope this pill is for me !
Il keep at it see how I go thank you xxx

[Vicky81]

When I have ever taken progesterone/progestins they make me feel worse for about 3 days as they are displacing oestrogen from the tissues. Once that passed through the bowels, there was an immediate sense of relief.

Definitely keep at it for a few days at least.

sorry hun I'm no good at this ....but what do you mean displacing estrogen? I'm still on the patch estrogen patch.....do you mean it's getting rid of estrogen from say a previous estrogen or combined pill through the tissues? If yiu coukd kindly explain like I say I'm not that hot on all this ....I hope you reply xxxxx

[dangermouse]

If I try to explain it, I will not be scientifically correct as it’s so complex!

In layman’s terms, there is a fine balancing act between progesterone and the other sex hormones. Hence, we take progesterone to calm down oestrogen’s ability to grow cells so, yes, it does have a lowering effect.

We also store a lot of oestrogen in the tissues, that does not show up in blood tests, which tends to be the more dangerous type and when we lose weight from fat cells or have high levels of progesterone in the blood, this oestrogen will enter the blood stream and go through the bowels to exit.

[Vicky81]

Ahh ok so is this a good thing for me? As in side effects or anything to worry about?
Like I said I'm still going to be on my estrogen patch too ....I justxwabted a progesterone only pill that woukd siuppressthe ovaries as I've been fluctuating badly.
Am on the right path you think? I started Slynd progesterone today.
So I need to allow it to settle? Cos obviously as bombsh3ll said I'm still bleeding as it won't stop that straight away
So am I safe abd doing the right regime (,up to now) ?
Xxxx

[Vicky81]

If I try to explain it, I will not be scientifically correct as it’s so complex!

In layman’s terms, there is a fine balancing act between progesterone and the other sex hormones. Hence, we take progesterone to calm down oestrogen’s ability to grow cells so, yes, it does have a lowering effect.

We also store a lot of oestrogen in the tissues, that does not show up in blood tests, which tends to be the more dangerous type and when we lose weight from fat cells or have high levels of progesterone in the blood, this oestrogen will enter the blood stream and go through the bowels to exit.

And when u said you felt crap for 3 days in what way,? Plus the reply above was for you hun xxx

[Vicky81]

So update and need reassurance.. ..3am night sweat.still bleeding quite a bit really, woke with more anxiety.  It's 5am ish now.
Is this normal?
Should I up my patch?
Or is it the fact the pill hadn't suppressed yet? Whst shoukd I do?
Anxiety driven here and to be honest i dont have alot of confidence in myself or with life ive gone into my shell alot lately thsts why i guess the reassurance helps me so much h on here . So pls be kind i know you will but I'm very alone down here my new partner doesn't know much about all this and I get so anxious. Don't know what I'd do without you ladies here honestly I mean that so thank you for being here (even if I've repeated ) you bear with me ..  thsnk you it means so much to have you all.
So - back to Slynd-
Do I keep going on with Synd?
 plus do I have to take it at the same time rigid everyday?
 do u think im still fluctuating? That us the main question id like answering please even my partner be4 he went work said ask those genius ladies (he meant that whole hearted as hes seen and read the replies youve already sent .. .he was blown away  honestky saying these women are far better than your dopey GP)he and myself  want to know if im  experiencing fluctuations still and is that why I'm still bleeding and getting night sweats??that's the main question I guess from him too  please.  Sorry I'm just anxious and woukd love answers/reassurance.- the reassurance is more what I need right now as I have a little 1 to look after and I'm a nervous crying wreck....please just tell me I'm still fluctuating so I know and can reassure myself that "this will get better" in my mind.  you ladies have already been so good, but please id be over the moon if you coukx settle me and ny racing anxiety over this,....and one last one - how woukd I know this slynd isn't working or suppressing may sound stupid? But how long would you give it ?
please help xx
Love vic x

[lizzy76]

I’m sorry you’re feeling so anxious. I have a lot of problems with progesterones making me drowsy so I take it in the evening- I find about 6pm is good. I thought I’d suggest that as you said you had taken it in the morning. I think it will take at least a few days for you to get used to it- maybe even a few weeks or more for the drowsiness to settle completely. I don’t have any experience with slynd in particular but it’s next on my list to try. I think it’s good for people who are sensitive to progesterone so hang in there and hopefully it will slowly improve. You probably need to give it some time for it to suppress the bleeding as well. Good luck x

[bombsh3ll]

I think you just need to choose a regime and give it a chance - it is reasonable to test a new hormonal treatment for 3 months or so (unless there are intolerable side effects that clearly started only after initiation)

It can take weeks to achieve ovarian suppression, and I hesitate to use that term with slynd because whilst it stops ovulation in the majority, it still permits a degree of ovarian activity otherwise it could not be used as a sole agent in birth control as all those young women would end up with osteoporosis. Same as a single dose of desogestrel.

If you want true ovarian suppression I would suggest 150mcg of desogestrel (2"cerazette pills) daily, alongside whatever estrogen you choose.

The post above is semi correct in very simple terms that taking continuous progestogens negates some but not all the health benefits of estrogen by down regulating receptors.

However there is always a tradeoff to be made - if you want ovarian suppression and hormonal stability for overall quality of life, mental health, avoiding bleeding etc the progestogen does have to be taken continuously.

I am on a combined pill for ovarian suppression and I accept that in order to reap the benefits.

If you preferred you could do a cyclical regime but this wouldn't shut off your own hormonal fluctuations and could lead to chaotic bleeding and more mood instability.

[Vicky81]

So bombsh3ll what shoukd I do? What woukd you do? I'm still fluctuating right?
Woukd yiu give slynd a chance or leave it as I'm sensitive to medications .....shoukd cerazette be my next choice?
Shoukd I just go onto 75 cerszette and see as I'm in tears now I don't know what the hell go do .....have you tried it ? Did it make yiu fatigued???

[Vicky81]

I’m sorry you’re feeling so anxious. I have a lot of problems with progesterones making me drowsy so I take it in the evening- I find about 6pm is good. I thought I’d suggest that as you said you had taken it in the morning. I think it will take at least a few days for you to get used to it- maybe even a few weeks or more for the drowsiness to settle completely. I don’t have any experience with slynd in particular but it’s next on my list to try. I think it’s good for people who are sensitive to progesterone so hang in there and hopefully it will slowly improve. You probably need to give it some time for it to suppress the bleeding as well. Good luck x

I've sent you a private msg liz