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[Nanookster]

Hi everyone,

I’m hoping someone might share their experience or thoughts on this. I’ve recently been put back on Bijuve (1mg estradiol + 100mg progesterone, daily) after struggling emotionally with 14 days/month of 200mg Utrogestan. I’m now also using one pump of Estrogel every morning, because I feel so much better on a bit more oestrogen.

So my daily hormone intake is roughly:

1.75–2mg of estradiol (from Bijuve + Estrogel)
100mg of daily micronised progesterone (from Bijuve)

I’ve read some sources saying the ratio of oestrogen to progesterone doesn’t matter — that 100mg of progesterone daily is sufficient for endometrial protection, regardless of a slightly higher oestrogen dose. But I’ve also seen others suggest that adding extra oestrogen should mean adjusting the progesterone too.

Has anyone else been on this kind of combo?

[Dotty]

Hi if the progesterone in Bijuve is the same dosage as Utrogestan, then 100mg can be used up to 3 pumps of Oestrogel or a 75 patch or 3mg oral oestrogen.

Any high doses of oestrogen need a dosage of 200mg of Utrogestan / micronised progesterone.

This is guidance from the BMS.

[bombsh3ll]

We are all different and it is difficult to say a particular dose of one formulation equates to a particular dose of another across the board due to individual variation in absorption and metabolism.

Additionally the amount of progesterone that controls one person's endometrium at a given level of estrogen may be insufficient for another, so generally manufacturers and prescribers tend to err on the side of caution and have everyone on a dose that protects the highest risk women, even though this means others are over treated.

You are still on a low dose and in all probability that dose of progesterone should cover you.

However my advice to anyone on a more individualised regimen, particularly when mixing and matching different formulations or adding extra estrogen to a fixed dose combined product would be to get a scan once a year or so to make sure you aren't developing hyperplasia.

[Nanookster]

Thanks @Dotty - what is considered a big estrogen dose?

[Dotty]

https://thebms.org.uk/wp-content/uploads/2024/12/01-BMS-GUIDELINE-Management-of-unscheduled-bleeding-HRT-NOVEMBER2024-A.pdf

Hi pages 13 and 15 give you the doses and how much progesterone is advised.

4 pumps of gel or 100 patch is regarded as a high dose.