AlfieBo, it sounds like some kind of histamine intolerance or mast cell activation syndrome issue to me. Have you looked into that?
Google the words 'Tina Peers estrogen histamine intolerance' and then basically google Tina Peers and read/watch everything she has to say.
She also has her own private menopause clinic which specialises in HRT and histamine intolerance. If I need estrogen again I will try to see her or someone at her clinic next time, instead of Newson. Because my Newson doctor was useless with my estrogen related side effects, even after telling her I'd been to A&E....