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[walkingthedog]

Desperate for help if anyone can give it

Came into hospital last Saturday l visit a a and e with abdominal pain which was found to be caused by two tennis ball sized cysts on my liver, sorted now pain gone.
However they won't let me leave as I have raised Crp levels of 200+ I have had every test imaginable 2 ct scan an mri anuntrasoundx rays endoscopies hundreds of blood tests, they have no idea what are causing these raised levels.

This morning I googled hrt and raised Crp and there's a link between estrogen and cpr raised levels. However I not scientific and don't understand the articles as from medical journals.
Please has anyone any knowledge or experience of this. I am beyond desperate to get home I don't feel ill, and as the tests  show nothing I'm now sure it's got to be linked to the hrt.
For reference I had a total hysterectomy in March 20 7and have been using sandrena 0.5mg daily

[Butterfly22]

Hi sorry to hear the week you've had, glad your no longer in pain. Sorry though I can't help as not that great at all this hrt, just wanted to say hope your home soon xx

[Foxylady]

Hi walkingthedog, sorry to hear you have had such an awful time. The only comment I could make re CRP is that it is an infection marker. I have no knowledge in relation to raised CRP & HRT, have you been attending any meno specialists that you could refer the hospital docs to so they can discuss this? Will they not even let you out on pass over the weekend if you promise to come back Monday am (might be an option! if you are otherwise well). x

[bear]

Hello walkingthedog,

Sorry you're going through so much distress. Have a look at the section 'Is there anything else I should know?' in this link https://labtestsonline.org.uk/tests/c-reactive-protein  HRT is mentioned, but I have read some scientific studies and they say transdermal estradiol don't raise CRP levels as much as oral estradiol (HRT or BCP).

The hospital staff is probably trying to rule out other causes before discharging you, because there are more serious issues that can raise CRP levels, but I think the liver cysts could be the culprit IF one or both have burst. Is that the case? CRP is produced by the liver, so it can leak to the blood after liver injuries or lesions.

Do you have any other symptoms, even mild ones, that you could share to help us help you?

Fingers crossed for you.

BeaR.

[dangermouse]

Not sure if it helps but I have benign liver cysts and the doc said they were caused by high oestrogen (perimenopause for me) and were also common in pregnancy.

[Hurdity]

Hi walkingthedog - haven't seen you for a while

So sorry to hear you're in hospital and do not yet have a diagnosis but pleased you feel well.

Interesting about the liver cysts because like dangermouse I have them too - several about 2-3 cm in diameter. I wonder if they continue to grow? Mine are benign fluid filled cysts and docs are not concerned so I'm not. Blood tests taken recently for other symptoms have all been normal.

Can you tell us something about yours ie how they dealt with them and what they say the cause might have been?

Sounds like you are in good hands with your docs being thorough and ruling out anything sinister.

I don't really know anything about CRP but I also found as bear did that oral and not transdermal oestrogen increases it.

There are lots of papers around and it seems that it is an "acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation ".  There is a very detailed paper about it here: https://www.frontiersin.org/articles/10.3389/fimmu.2018.00754/full

Sorry I can't be of any more help but hoping you get let out soon and in the meantime have a

Hurdity x

[Hurdity]

PS I'm sure you've read loads about liver cycsts but there is some info here (scroll down for info about simple liver cysts).

https://www.britishlivertrust.org.uk/liver-information/liver-conditions/benign-tumours-and-cystic-disease/

Hurdity x

[CLKD]

Better to be kept in than have to return in a hurry when the bed might have been taken!

Ask for a Care Team meeting where everyone involved gets together with you and discusses!  Or get the patient care group, it's PALS in some Hospitals, to ask on your behalf?

[bear]

Sorry, I was going to edit my post and deleted it!

I've read that CRP levels above 200 mg/L can indicate active bacterial infection, so I thought one of the liver cysts could be infected, but then I remembered that your other blood tests results are normal, so that might not be the case. I wonder if some medication you took in the hospital could have caused some reaction? Still investigating...

BeaR.

[walkingthedog]

Thank you for your replies
I asked the consultant if the hrt was linked, he said it can raise crp but not to the level I have.
The cysts are unrelated to the crp I have had them anout 7+ years originally 2 and 5cm now 18 and 15cm yesterday I had an mri detailed liver scan which showed a healthy liver no infection same as every other test, all fine except the crp. Consultant says there's an infection somewhere but they can't find it so this afternoon he discharged me much to my relief. He has referred me to see a liver specialist and said that the crp was a case of seeing if I get ill or not.
I can't eat much and tire easily as the cysts are taking up so much room and pressing on my stomach. It's a case of getting by until I get appointment see specialist or go back to emergency specialist care service if pain starts again
So basically I'm convalesing

[CLKD]

Get those feet up!   Let the Staff do the testing that is needed, don't be pushed out until you feel you R well enough!

[Katejo]

Thank you for your replies
I asked the consultant if the hrt was linked, he said it can raise crp but not to the level I have.
The cysts are unrelated to the crp I have had them anout 7+ years originally 2 and 5cm now 18 and 15cm yesterday I had an mri detailed liver scan which showed a healthy liver no infection same as every other test, all fine except the crp. Consultant says there's an infection somewhere but they can't find it so this afternoon he discharged me much to my relief. He has referred me to see a liver specialist and said that the crp was a case of seeing if I get ill or not.
I can't eat much and tire easily as the cysts are taking up so much room and pressing on my stomach. It's a case of getting by until I get appointment see specialist or go back to emergency specialist care service if pain starts again
So basically I'm convalesing

Really hope that you feel better soon. I can't advise on liver cysts but can empathize because I am feeling unwell and sorry for myself at the moment. 

[bear]

Hi again,

Glad you're back home. Those cysts are huge! Did the consultant tell you why? Couldn't they be causing inflammation in other organs, by pressing on them like you said? How long will you have to wait to see a liver specialist?

BeaR.

[Foxylady]

Glad your home walkingthedog, take time to rest and look after yourself (or even better if there's someone else there who can look after you! ). I hope you don't have too log to wait for specialist appointment & first signs of becoming unwell (especially as you know you have raised CRP) get back to GP or hospital. x