I've split your post in order to read it more easily.
You should have been better supported by the medical profession in that HRT could have been prescribed in order to protect heart and bones! Given the fact that you were presumably under regular hospital appts., at a time when you were unable to conceive, your hormonal future should have been considered. However. If the ADs work, stick with them. Some do help hot flushes etc. ;-)
But despite everything that's happened I feel the hardest part and the most saddening is the effect and break down of my friendship with my best friend. We have been like sisters since we were 16. It may be that if she hasn't been through infertility or menopause that she has no empathy? Therefore you may have come over as 'clingy' and if you are ageing at the same time, she may be less able to cope with problems from others? ** Although you have eased her personal experiences, sadly support don't always get reciprocated. I understand where you are kind of coming from, when I moved miles away from a very tight circle of friends I was the 1 who had to keep in touch - otherwise I heard zilch. I was aware that their lives were now running parallel to mine, but *I* was the one who had moved ..........
I've had so many other friends around me that have supported me and reminded me that I'm a great friend to them and that they are here for me. Friends I never expected. - maybe they weren't as heavily involved or maybe you didn't see them as often? Therefore they didn't feel hemmed in by your situation?
" she responded that I wasn't a burden but she did feel she was walking on eggshells around me. " she has responded with this so even if you don't feel it, you do realise that you haven't 'been yourself' and may not be aware of how you 'came over' to others. Certainly it's a fault of my own

and friends have to pull me up occaionsly. I get a bit grumpy when they do

'cos I don't see it.
Friends have boundaries and strengths too. It would be arrogant for any of us to believe that we really know everything about another, however closely lives are entwined. Maybe she had situations that she was finding difficult when you were with her? Perhaps she couldn't get a word in edgeways? or didn't like to interrupt in order to make the convesation less one-sided.
R U still in contact with her? You didn't like her response about 'eggshells' but the truth often hurts! Friends should be honest with each other. White lies when necessary .........
Have you had contact with the Daisy web-site?
**. I have had to back off from listening to my Mother as I've been feeling quite unwell in recent weeks. I have visited with her less without being too open about why as I need to sort stuff B4 I next go to see her.