Hi Stardust
I was told my oestradiol level was too high at 1768. I was suffering major panics, anxiety, and feelings of doom. That was in November. As I had missed 3 periods at the time I was given 100mg progesterone only to "balance things out" - it was supposed to help me. Although I have only been taking the progesterone since Feb, I can honestly say that it has done nothing at all for me. I agree with Tempest - I think it must be the fluctuations of hormones that are causing all the problems. I am 50, and as yet have had nothing that agrees with the normal description of a hot flush. But when the depression hits, its like a light switch goes off in my head. It is very sudden, like I can almost feel something surge/drain inside, just like GypsyRoseLee describes. But these spells can last for weeks at a time, and I too have wondered if this is actually hormone related. I also think its all the other things, like headaches, dizziness, hairs, odd pains etc. Taken as individual things they would not be a problem. When they all come at once but are quite non specific I think that just adds to the daily anxiety which is already being fuelled by the hormones enjoying a trip on a rollercoaster. In my experience anxiety promotes more anxiety. I'm not sure what the answer is, but its good to share experiences.