Thanks ladies,  Sally G what treatment did you go on to make you better?  Lizab have you been to your GP and explained your symptoms?  
Yesterday was awful for me, there was a monster in my house and unfortunately I realised it was me!  I literally couldn't speak to anyone in my house, as everytime I opened my mouth I was vile!  I took myself off for a swim to try and elevated these feelings, but I didn't get much relief.  I am exercising most days when I have the energy and really I should be buzzing and on top of the world but I'm not I'm a moody cow who is a nightmare to live with.  
I am seriously considering asking the dr to change my AD's, I've been on venlafaxine (various strengths) for over 6 years and I've never liked it as it has horrible side effects if you forget to take or if you are unwell (vomiting),  I have argued it's benefits before but the dr has not been keen to change it.  I have been on various AD's since my early 20's due to serotonin deficiency and severe PMT, which explains all this madness I am now experiencing.
Any feedback with regards to AD's would be great.  Starting patches this week and praying that I get some normality back, cross your fingers for me please.