thanks again Taz and Karin, unfortunately don't start back on the estrogen until a week Saturday roll on, Karin Im the same, sleepless nights due to sweats and anxiety, though not so many flushes in the day, but its the other funny effects that worry me, I get food cramp, leg aches and I think blood clot, silly but cant help it, and chest pains and then I think heart attack scary! I also find my head all over the place and find it hard to concentrate at work, I worry about my job then, vicious circle really, I also feel like I look like a mad women walking round as I feel Im starting to look as if all this is taking its toll, todays another day hope its a good one, Karin maybe its it pmt with me as I burst out crying last night also, joy! when are you back on the evorel 50? hopefully you should be fine again then x