Gynest, Ovestin and Vagifem made me burn. I think my VA was so bad in my urethra that I was sensitive to everything. Maybe, if I'd persevered for a few more months, the burning would have subsided as the oestrogen did it's magic. I'm using the Estring which is just a latex ring that slowly releases the oestrogen so there are no fillers to irritate. It still took over 4 months before I started to feel comfortable. Dg x