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Low dose combined HRT may be helpful for diabetic women

10 January 2007

A team from Glasgow has looked at the effect of low dose continuous combined (estrogen in the form of 1mg estradiol and progestogen in the form of 0.5mg norethisterone) compared with placebo on glucose and cholesterol levels in postmenopausal women with type 2 diabetes. Twenty-eight women completed the study. The women taking HRT had lower fasting glucose and total cholesterol levels compared with placebo. No significant effect was seen on glycated haemoglobin (HbA1c), triglycerides, high density lipoprotein (HDL)-cholesterol or C-reactive protein (CRP).
Uncertainty has surrounded the use of HRT in women with medical problems such as diabetes but this small study has shown beneficial changes in the women taking HRT and no detrimental effects in the parameters measured. Ref

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