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[Yorkshire Girl]

I still lurk on this thread.

[Sammiejane]

Hi ladies please help

I had a total hysterectomy and oopherectomy in 2014 age 35 for severe pelvic pain and adeyonmeosis why they took my healthy ovaries I have no idea !

Anyway have had no meno Symtoms for over 4 yrs then in July of 2018 I was hit with vaginal dampness but nothing else occasional hot flush but I managed these

I decided that the dampness must be calmer for having no HRT all that time and I did try it straight after my op but the one patch didn't suit me and GP just dismissed trying others so I went cold turkey ! Anyway forward to September 2018 I decided I would try it again and a different doctor perscribed the same patch as before which was elleste solo mx40 but I thought maybe I would react different now 4 or so years later and was fine intill 5 weeks into taking it then the diadem effects hit chest pain breathlessness and I could raise my arms that felt so heavy I had headaches blurry vision so GP said stop them and referrred me to meno specialist and gyno for the dampness.

I saw gyno first and they perscribed vagifem and suggested the dampness was VA as no prolapse present so was now taking vagifem nothing else and 5 weeks into taking this my hair started shedding and thinning I was gutted because my hair did the opposite after my op and went really think and grew dead quick wether I had slightly higher testosterone I don't know

So I swapped the vagifem to Ovestin and am still on that then on dec 25th 2018 started estrogel 2 pumps but my hair is even thinner mainly scalp thinning and I don't feel brilliant to be honest have now gained stone in weight losing my hair can't sleep Terrible aniexty depression. Low confidence and prior to started HRT I had actually lost weight after my op by stone and half I'm constantly bloated constipated and sluggish

I get exessive sweating clamy feet which gyno and GP have said hormone imbalance between estrogen and progesterone and testosterone.

Is the estrogel causing my hairloss ?

Also I'm not obsorbing the gel well even though I felt it was working for my VA symtoms so I'm now stuck what to do

I was thinking about the contraceptive pill combined as had no issues on this before .

Do I increase gel and add progesterone to balance out the estrogen effects ?

Or swap to a patch only estradot

Or combine estradot patch with utrogestan and see if hairloss stops

Can you ladies advise have you had hairloss on estrogel and utrogestan ?
Estrogel only ?
Estradot only ?
And estradot and utrogestan ?

Thank you

[Yorkshire Girl]

Blimey Sammiejane I'm not going to be much help, just wanted to say I really hope you get it all sorted with the right medication. I have had none of those symptoms and I've had a total hysterectomy and oophorectomy. I expect you know there is no need to take progesterone. Hopefully someone else with more experience will be along with some help. Good luck x

[atherineca]

Hi all

I am new to this site, sorry if this post is so long  ..... I had a total hysterectomy nine years ago and went straight into surgical menopause.  I was never offered HRT. 
I have suffered with hot flushes with aura ( I know when one is coming as I feel nauseous & weak/faint) then the heat rises.  I also suffer with brain fog, bloating, anxiety, depression & lightheadedness.

I suffered with anxiety before I had an hysterectomy & I took antidepressants from 2003 to 2012.  In the end I took myself off them as the weight I gained on them really depressed me.  I went from a slim size 14 to a size 18/20.

So I have been suffering with the hot flushes etc for 9 years!  Hoping they would go away. 

I went to see my Doctor a few weeks ago and she mentioned taking HRT.  But I have a sister that has had breast cancer and there is a great deal of heart problems in my family too.  Both my parents, my brother, his 2 son's, my grandfather, 2 aunts and a uncle.  Also I just turned 60 last month.  So you can see why I'm hesitant to take it.

My Doctor then wrote to a Consultant in Gynaecology because of my concerns and she suggested I try 0.06% oestradiol gel 2 pumps daily.

I hear so many conflicting views.  Some gain weight, others don't, some women feel great on it, others don't etc. 
I've put up with it for 9 years, maybe I should ride it out?  I'm so confused.

I'd like to add that 2 years ago I had my thyroid checked and was told it was border line.  I am due to have it checked again next week.  Should I wait to see what those results are before starting HRT?  If I decide to go ahead.

[Joaniepat]

Hi atherinica, welcome to the forum.

This is just to say that you can always start low with the gel, do one pump a week for a couple of weeks until you get used to it, then increase to two. Transdermal is quite safe as it doesn't go through the liver, and you (and I) are lucky in not needing progesterone. I'm sure you'll be fine, and you have suffered quite long enough with the flushes. Just give it a bit of time to sort out that and the other symptoms.

Let us know how you get on with the thyroid check next week.

Best wishes,

JP x

[atherineca]

Hi atherinica, welcome to the forum.

This is just to say that you can always start low with the gel, do one pump a week for a couple of weeks until you get used to it, then increase to two. Transdermal is quite safe as it doesn't go through the liver, and you (and I) are lucky in not needing progesterone. I'm sure you'll be fine, and you have suffered quite long enough with the flushes. Just give it a bit of time to sort out that and the other symptoms.

Let us know how you get on with the thyroid check next week.

Best wishes,

JP x

Hi JP

Thank you for the welcome 

That is a good idea to start low.  Do you use oestradiol gel yourself?

atherineca x

[Joaniepat]

Atherineca, I have used Oestrogel in the past, and was told to use one pump for two weeks to start with, before increasing to two. There are loads of people on here who get on fine with it and like it's flexibility, as you can even go up by half pumps.

JP x

[atherineca]

Thank you JP  x

[Sammiejane]

Hi tempest

Could u let me know what hrt regime u are on .

Thanks

[Winterose]

Atherenica

I was borderline for thyroid and my doctor said she treated borderline cases as it stopped heart issues later on. Within 6 months all my joint pains were gone and body temp increased from average of 34 to 36. I had hysterectomy but insisted on keeping overies . It was 14 years ago and I use evorel patches

[atherineca]

Hi Winterose

Thank you ... That's interesting to know.  Could you tell me what medication you took/take for your thyroid please?

atherineca

[bear]

Hi girls,
 
I came across this article today and I thought this might be a promising neurotherapy for all surgical menopausal ladies who struggle with anxiety, depression, brain fog, memory issues. It's a prodrug α-DHED that is converted to αE2 in the brain, showing antidepressant-like effects in mice, without the need to use progestogens, because it doesn't act in the uterus.
 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6582959/

BeaR.

[Hurdity]

Thanks bear - what is the drug marketed as?

Also if it has oestrogen effects on the brain without effects on the uterus and therefore no progestogens needed - then the new medication may be of interest to all women who suffer with residual anxiety and depression and for whom HRT is either contraindicated or who have persistent symptoms even with HRT, as well as those who are in surgical menopause.

Hurdity x

[bear]

Hi Hurdity,

The drug (DHED) has not been marketed yet. The authors have a small company in Texas, Agypharma. They're probably waiting to sell their idea to a big pharma company.

https://twitter.com/agypharma
https://www.inknowvation.com/sbir/companies/agypharma-llc

They also have published this article on the beta version of their drug for hot flushes:

https://www.nature.com/articles/srep30721?platform=oscar&draft=journal

BeaR.

[Maxwin]

Hi Atherineca, we could be twins!  I also turned 60 last month and had total hysterectomy 9 years ago and relate very well to being plunged into a surgical meno    I do take very low dose hrt patch everol 25 and although I do still get night sweats when I did try to come off it I realised it definitely takes the edge of them, so for me I'm staying on hrt.  I also have underactive thyroid and take one 50 microgram levothyroxine tablet a day.  It really is such personal choice and a lot of thyroid symptoms mirror menop ones so its even more difficult to know whats going on.  All I can say is good luck I really hope you find a balance.