Hi Jefner sorry in delay replying. I had moved up to the full patch (Everol 50) I think I was about 6 weeks in. I took the patch off and felt better within 24hrs! I have tried various forms of HRT, tablets, patches, gel and utrogesten virginally but still end up feeling worse within 6 weeks so rightly or wrongly I stop taking/wearing the HRT. I know alot of people say give it 3 months but when you feel like that after 6 weeks your not gonna carry on with it in the hope it will improve. I think I have got to the stage that my meno symptoms are better than the side affects of HRT (have hot flushes which are thankfully dying down but I am 5 years post meno) and I get anxiety just before a hot flush. As I am only just 50 I am well aware that I should have sone form of HRT but not sure if I am brave enough to try anything else at the moment!!