I'd use it inside and outside every night initially then reduce it when you feel comfortable. The maintenance dose of twice a week is not enough for a lot of women and the doctor can up the dosage if needed. Use the steroid cream as prescribed, mines twice a day for 4 weeks then twice a week but I've never needed to use that much, I'm usually ok after a week or so. I usually use the steriod cream about an hour before using the Estriol cream, not at the same time. The steroid cream will help with healing the skin, as it's so sore the Estriol might sting to start with. You can use it with your moisturiser too. Which cream have you got? The small Estriol 1mg 15g tube or the larger estriol 0.01mg. Both work but with the larger tube you can spread it on more liberally.