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[fryernikki]

Hi everyone, I’m wondering if anyone has had a similar experience with very high estrogen on Estrogel. I’m post-menopausal after a full hysterectomy. Back in April, while on Evorel 100 patches, my estrogen was 143 pmol. My gynae switched me to 4 pumps of Estrogel daily, and my recent November test came back at 2172 pmol.

It’s a huge jump, but I haven’t had any obvious high-estrogen symptoms. My gynae now has me on 3 pumps, and I’m feeling quite anxious about the risks and why the levels went so high. They didn’t seem too worried, but I’ve asked for another blood test in case the result was off.

I was also taking testosterone but stopped recently, and I’m wondering if that could have affected things. Has anyone else experienced anything like this? Any insight would be really appreciated. Thank you

[CLKD]

  

I don't know much about replacement therapies.

1st how old R U and why did U stop the testosterone?

Hopefully some1 will be along with advice.  Browse round.  Make notes ;-)

[sheila99]

At that reading it's far more likely to be contamination than genuine. Estrogen on particularly is very easy to spread as it's on your fingers so can get anywhere you touch.

[bombsh3ll]

When you say a full hysterectomy I am assuming you mean including BSO.

As Sheila says this is likely contamination.

Blood results on gel are notoriously unreliable anyway due to the pharmacokinetics - if you catch the peak soon after applying, there will be high plasma levels, however a few hours later it has largely left the plasma and can appear low.

For this reason I would never use plasma estradiol to guide treatment decisions on gel.

In many cases therapeutic efficacy can be assessed clinically.

Where there is a particular health goal, if gel is the only acceptable route then other markers of efficacy can be followed such as serial DEXA or coronary artery calcium score.

I personally believe there is also mileage in using indirect biomarkers such as FSH and SHBG however these have not been validated and are not currently used in clinical practice.