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Author Topic: Switching from sequential to continuous HRT  (Read 523 times)

secret.sherlock

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Switching from sequential to continuous HRT
« on: October 15, 2025, 06:01:10 PM »

Hi all,

I'm in need of advice. I've been dealing with perimenopause symptoms for 9 years and I'm worn out.

Went on HRT a couple of years ago, Oestrogel and Utrogestan for 12 days every cycle. Always had a withdrawal bleed at the end of the 12 days until recently. For the past couple of months, it has been very light. The last cycle there was nothing. Then 2 weeks later, I started getting cramping, tenderness, etc and now I've had a period. Thing is, this is the day I'm meant to start the 12 day Utrogestan. So do I take it tonight or start counting 14 days from now and then take it?

GP said I could think about going continuous or wait till my next birthday (I'm 49). If my own hormones are reducing further, I might as well start now. But how do I do that? Start taking one every day now?

Can't get an appointment with the GP, can't talk to her on the phone. I don't know what do.
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sheila99

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Re: Switching from sequential to continuous HRT
« Reply #1 on: October 15, 2025, 07:26:47 PM »

The old version of conti might be useful where you take it for 25 days out of 28. This allows a bleed if there's been a build up. Be aware that if you go on conti too soon you're likely to have breakthrough bleeding which may lead to unnecessary intrusive investigations for 'unexplained bleeding'.
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secret.sherlock

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Re: Switching from sequential to continuous HRT
« Reply #2 on: October 15, 2025, 07:40:10 PM »

Thanks, I appreciate the advice.

What you said is what the GP said too at my last appointment, wait till my next birthday next year by which time I'll have been on HRT for 4 years.

I'm happy to stay on conti but what do I do now? Do I restart the clock and wait 14 days before starting the Utrogestan?
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sheila99

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Re: Switching from sequential to continuous HRT
« Reply #3 on: October 15, 2025, 08:08:19 PM »

Medical advice is to continue with hrt cycle regardless of when/if you bleed. If you don't have a strong cycle of your own you may as well, if you do imo it's better to change the hrt cycle to fit on with your own.
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bombsh3ll

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Re: Switching from sequential to continuous HRT
« Reply #4 on: October 15, 2025, 08:39:20 PM »

Personally I am not a fan of using sequential hormone therapy in perimenopause because trying to synchronize it with an ongoing natural menstrual cycle is like playing pin the tail on the donkey. Every month. It's a mug's game.

The bottom line is you can do whatever you want with the progesterone as long as you take the prescribed amount in a given time period, or at least don't deviate from it by much.

If you are prescribed 24 or 28 capsules per month, you can take 2 daily for 12 or 14 days, or one daily every day, or like Sheila said one for 25 out of 28 days.

If you don't mind all the bleeding it is absolutely fine as long as you are taking the minimum amount to protect your endometrium.

What I would not do is wait for day whatever of your cycle to either start it or stop it. This tends to result in undertreatment in perimenopause because either periods become closer together so you end up with say far more day 1's and day 2's than day 14-28's. Or in late peri cycles become infrequent and you wait weeks for another "day 1".

So if someone is really wedded to sequential micronised progesterone in peri it is often better to use day 1 of each calendar month and just accept the chaotic bleeding than tie yourself in knots trying to predict it.
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