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[Ms_london76]

Hi everyone

It has been awhile since I posted. Started with vaginal dryness and bladder issues, sleep issues, small wound in the vestibule.

I had been on Imvexxy since last November. Nothing really improved. I started hrt In June and over a week ago many things have changed.

Sleep much better, bladder holding longer. I had a fake period maybe at around 10 weeks. But the most recent development has been the return of vaginal secretions.

There seems to be a pattern where I am more irritated and drier after inserting  Imvexxy. Today 3 days out of Imvexxy and lots more secretions.

In the beginning Imvexxy would feel comfortable the next day and the next. Now the opposite is happening. I suspect cuz I am getting more estrogen my tissues have been changing.

It’s been a pattern the last two weeks?

Wondered if anyone else had this happen to them? My dr wants me to stop local for a bit to see if systemic can carry the load?

After being in Imvexxy for so long hrt seems to be the main driver of change at the moment.

[CLKD]

What does up has to come down?  It may be that your vagina is lubricated better with regular treatment? 

I wouldn't worry about secretions if there is no odour.  Keeping on with my regular regime with 'estriol' has helped me.

[Ms_london76]

Oh I totally get that. Except what comes down is the next day with imvexxy which a pill  maybe a little bit the second day. However the increase in secretions on the vestibule is very new and happens more on days where I am furthest away from Imvexxy itself.

It’s hrt that has changed things and turned my glands on. The issues was not really the vagina but the vestibule itself where Imvexxy never reaches fully.

[bombsh3ll]

Personally, and I know not everyone shares this view but it is my opinion that if someone has a healthy level of systemic estrogen, then unless there is a specific issue relating to pelvic blood flow, scar tissue, radiation or neuropathy etc, they should not have GSM.

GSM is caused by a lack of estrogen, and doesn't occur in women with healthy, unimpaired ovarian function.

Given the biological implausibility that every other estrogen sensitive tissue is thriving at a particular level of replacement whilst your vagina is uniquely atrophying, I personally would not use vaginal estrogen as it can mask this helpful indicator of general estrogenisation.

I would rather have my vagina be the canary in the coalmine alerting me to systemic undertreatment given the impracticality of getting a DEXA and a coronary artery calcium score every few months.

[Ms_london76]

It is quite interesting to learn now upon some research that local therapy can actually make you more dry. Depending on the state of your tissues.

I recently started showing secretions real moisture and on the following dsys (2) those secretions turn into a clear film. Than in day 3 (away from local) they come back. Apparently this is a thing, when tissues are healing.

When I first started Imvexxy would provide relief the next day and maybe into the following day. Now that my tissues have been changing under hrt it is causing dryness.