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[Alana]

 Some advice please.
I put my HRT prescription into chemist only to be told a week later that Premarin is unavailable and has been for some time.
I asked for an alternative similar to Premarin and was prescribed Estradiol. Have been on them for 2 weeks but find that I am lethargic and feeling anxious. Does anyone know of a better alternative?
Regards
Alana

[bombsh3ll]

It is hard to come up with an exact replacement for Premarin because it is equine derived and has a unique blend of estrogens and androgens.

Firstly can you get a different dose of Premarin e.g. if you take 1.2mg could you get 0.625mg and take two etc?

Alternatively you could try estradiol plus transdermal testosterone - make sure your estradiol is an appropriate dose; often when women have to change products the prescriber will try to covertly shrinkflate your dose so that you are not on the equivalent strength that you were taking.

If I were on 1.2mg of Premarin I would want at least 2mg oral estradiol or a 100mcg patch. So it may be a dose issue.
There is also oral Tibolone which is a synthetic compound that also contains estrogenic and androgenic components.

[Alana]

Much appreciated, thankyou

[sheila99]

The transdermal hrts are safer than premarin so IMO it would be worth trialling different options to see if you can find a suitable alternative. Lathargy is likely to be low oestrogen, anxiety can be both low and too much but given the lethargy yours is more likely to be low.