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Author Topic: HRT advice please  (Read 566 times)

JJRRCC

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HRT advice please
« on: June 01, 2025, 07:49:55 AM »

I’m just after a bit of advice really before I call my Dr regarding my HRT as I’m now wondering if my dosage may need tweaking and I was wondering if anyone might know if and how this would change (if at all)
I started HRT about a year ago. 2 pumps of gel  in the morning and 2 x Utrogestan 100mg at night.
When I began I felt such relief and my problematic symptoms went. I no longer felt like I wanted to kill anybody on a daily basis and I felt like myself again.
Lately though I’ve still been feeling fantastic up to day 15 like I can take in the world again however during the progesterone stage days 15-26 I have once again feeling lifeless and completely lacking in energy and motivation almost to the point that I dread this stage as it feels like I am not myself for well over a week and every day is a real struggle physically and mentally. This is how I would feel before HRT.
I was just curious about what to expect the Dr to suggest when I speak to her.
Thanks in advance for any advice x
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CLKD

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Re: HRT advice please
« Reply #1 on: June 01, 2025, 08:26:40 AM »

Morning. It may well be your hormones over riding the replacement - mayB put the product names into the search box: individually: and read the topics.  Make notes ;-)
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bombsh3ll

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Re: HRT advice please
« Reply #2 on: June 01, 2025, 01:44:20 PM »

It sounds like progesterone intolerance but it is a bit strange that you didn't get these symptoms when you first started it. I wonder if your underlying hormonal situation has changed for example lower ovarian estrogen production.

You could try taking the progesterone vaginally instead - it doesn't convert to psychoactive metabolites that way, reducing the dose is also an option but this really shouldn't be done without endometrial monitoring to ensure it is controlling your endometrium.

Alternatively you could consider a progestin instead such as the mirena IUS or daily desogestrel 150mcg or slynd as your endometrial protection. The latter two are off label but supported by evidence and increasingly used in practice.

Tibolone is another good option for progesterone intolerant women although you would have to say your periods had completely stopped to get this.

Anecdotally, a robust dose of estrogen and the addition of testosterone also make the progesterone easier to tolerate in some patients, although you would have to say it was for low libido on the NHS.
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