I started with much heavier periods and iron deficiency at 35. When I was 36 I had a short spell of night sweats and itchiness down below that was confirmed as not being thrush (with hindsight my first signs of decreasing estrogen).
There was a lull and then things really kicked off at 39 with heavy periods causing anemia. I also had bladder issues for a while. Another lull until I was 40, almost 41. It has been full on since then with on and off dryness down below, insomnia, mood swings, night sweats, itchy skin, occasional palpitations etc. I started HRT over a month ago and feeling so much better already

Peri has been working on me for many years, I'm 42 now.