Hi, sorry you're feeling so awful. I'll just share my experience, in case it's any help - I have been on ultra low dose Femoston Conti (.5 oestrogen/2.5 dydrogesterone, oral) for three years now, and I love it. Yes, .5mg oestrogen is very, very low, but it seems to be just enough to nudge me back into feeling more or less normal. If I try to up the dose (they do a 1mg/5mg version) I find that the increased prog makes me very grumpy and PMS-y. This might pass if I persisted with it, but as I feel OK on the ultra low version, I'm sticking with that. Might be worth a try?