Hi, I understand how you feel! I am not on the gel but I was using BiEstro estriol/estradiol topical cream for a while. Most days I was fine but around the time that I would have had a period (I still seem to be on a 28-30 day cycle, without the bleeding - it seems hormones still release a little and I notice such a difference at different times of the month).
I notice I cannot tolerate the estradiol or progesterone around that time - it sends me a bit crazy. I am agitated, impatient, I cry over nothing. So, for 7-10 days each month, I am not having either cream and sticking with estriol vaginal cream instead.
Just a thought that it could be something similar.