I haven't posted on here for a good few years. Just thought I'd pop on to mention my journey with oestrogen only transdermal HRT. I am 63 and had a hysterectomy 14 years ago. Ovaries were left but were removed around 4 years ago. I remained on my HRT and have no issues with that. I am someone who benefitted hugely from it. Various other health issues that I won't delve into too much, simply because it's complex and I'm pretty on top of it, but I have CFS/ME. I am sensitive to almost every type of medication/herbal remedy/ supplements. Not allergies per se, but just sensitivities that manifest as sneezing, itching, etc etc. I had changed from Estradot (or Evorel) patches to oestrogen. Can't remember why... think I fancied a change. However I seemed to have worse sensitivities to the gel. I get confused with timelines as I have so many auto immune illnesses but basically I decided to stop using the HRT as I only used a tiny amount anyway. Within 6 months I crashed and was aching every day, had pains in my finger joints... hot flushes with a vengeance and sweats. A fabulous Professor of rheumatology I was lucky enough to see a few months ago, and who consulted me in a holistic way (amazing physician!), rather than just focussing on one thing, discussed my HRT and said that it could be that I was sensitive to the other carrier ingredients in the gel and as I was back to being depressed and not sleeping at all, perhaps I should try (amongst other things he discussed with me) using patches again. I was a bit reluctant but thought I would give it a go. I kid you not, within a week of using Evorel 25mcg patches, I had colour back in my face, felt lighter in mood, my hair stopped falling out and my skin had a glow. Unfortunately though I have the fluid retention back (which I always had) and thinking I might cut the patches in half. I think I will be one of the women who stay on low oestrogen forever. I certainly felt like an old lady when I was off of it.