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[Gilla999]

I don't mean PMDD type Progesterone intolerance, I mean an actual allergy 

Keen to hear from them if so! x

[CLKD]

R U able to describe your symptoms? 

Allergies are different to sensitivities or localised reactions.

Many find the progesterone part of a regime hard work!

[Gilla999]

Hi CLKD, hope you're well 

Yes most of us dislike the Progesterone part of a regime! An actual progesterone allergy is quite different though - it's quite rare, but luckily easily diagnosed with a skin prick test. Because of how rare it is I'm not expecting to get any hits on here, but thought it couldn't hurt to ask 

[CLKD]

As well as sharing experiences so that others can consider it as a possibility? 

I'm OK after a strange reaction to an AD last week  .  It amazes me how different drugs/treatmens can affect people  .

For years it was considered that I was allergic to DH  ...... despite skin testing, not a lot was found, I've learned to manage my allergic rhinitis. 

How do women manage natural progesterone, I have never been aware of which hormone was responsible for periods etc.; it was all 'natural' and cyclical for me so it never crossed my mind, nor was I ever aware of ovulation. 

[Hurdity]

Hi Gilla999 - it depends which formulation of progesterone? There was someone who was allergic to one of them I think. Also depends what form the allergy takes? It is one of our natural hormones so you will have had it in your body all your life and in large quantities every month when fertile and in huge quantities if you've been pregnant.

Hurdity x

[Gilla999]

Hi Hurdity - Autoimmune Progesterone Dermatitis (APD) is the official name of the condition - it's an allergy to your own endogenous Progesterone, as well (usually) to all other forms of Progesterone, though some people do ok with synthetic progestins. It primarily manifests as urticaria and other cyclical skin related issues, and can begin at any time in life. It's quite rare, so I wasn't really expecting any positive replies, but thought it was worth asking!

CLKD sorry to hear about the strange reaction... was it a new medication, are you switching? I've been on a huge journey with my ADs over the last few years. It's so true about different people reacting differently to things!

[CLKD]

I began a thread when it occurred.

[Nicola Eyre]

Hello
I have trialled many different progesterones, pre menopause and post menopause since having a total hysterectomy in November 2021. All progesterones give me significent side effects. Stomach bloating, migraines, pains in my legs, mood swings. So i am now only taking estrogen which doesn't eleviate menopause symptoms really apart from hot sweats.

[CLKD]

Morning Nicola -    However, I don't think that you require progesterone.   . 

[Ali P]

Hi. It’s while since I was on this forum but I’d like to get in touch with Gilla999
Gilla999 if you don’t mind me asking. Who was your doctor and was he private when you used omalizumab
Thanks Gilla.  Ali P

[Penguin]

Hi. It’s while since I was on this forum but I’d like to get in touch with Gilla999
Gilla999 if you don’t mind me asking. Who was your doctor and was he private when you used omalizumab
Thanks Gilla.  Ali P

You could send her a dm and then she'd get notified via email that you'd contacted her on the forum?

[HRTStoleMySleep]

I don't mean PMDD type Progesterone intolerance, I mean an actual allergy 

Keen to hear from them if so! x

I know I’m coming to this discussion late but thought I should post anyway.
I believe I am experiencing allergies or hypersensitivities to both progesterone micro and estradiol. At the moment, I am taking only progesterone micro and have had the following experiences:
1) no noticeable allergic reaction to 100 mg plus 1/2 of a Zyrtec (this combo gave me dependable sleep every night for nearly two months - heaven!);
2) 200 mg with no Zyrtec - night 1: whole body diffuse itching with red rash that came on several hours after taking progesterone micro; night 2: whole body diffuse itching with red rash in some spots, 1 hive, swollen upper lip (again came on a few hours after taking the prog micro)

I had started on the prog micro alone to see if it was causing insomnia. A prior attempt at hrt (prog micro + estradiol patch) earlier this year had turned me into a complete insomniac for 8 weeks and I thought I’d give it another go. This time my menopause doc instructed me to try the prog micro alone without estradiol to see how I reacted. The prog micro alone + 1/2 Zyrtec resulted in beautifully dependable sleepiness at night and longer, more restful sleep. It was heaven!

Prior to this, I had been taking my own cocktail of Zyrtec + CBN patch + lemon balm + magnesium to help me sleep. When I started the Prog Micro without estradiol, I still took 1/2 Zyrtec thinking it could help with sleep, but when I saw how well the Prog Micro was helping with sleep, I decided to stop taking the Zyrtec. I had also stopped the CBN + lemon balm. It was when I stopped the Zyrtec that I noticed the allergic/hypersensitivity reaction.

I’ve experimented taking the Prog Micro with and without Zyrtec and can confidently say that Zyrtec suppresses the reaction. I can also confidently say that it’s the Prog Micro pill that’s causing the allergy as I have changed nothing else in my diet, personal products, lifestyle, etc.

I’m crestfallen because I thought I had found something that would help me get dependable sleep, but now am not sure whether I should take Prog Micro at all even though the Zyrtec suppresses my allergic reaction. I am going to make an appointment with my allergist but I know what she’s going to say.

As for my allergy to estradiol, I had a similar reaction to an estradiol vaginal cream. Labia swelled up but no itching. I thought my labia were just getting plumped up LOL. But then I tried the vaginal cream on my face and my upper lip swelled  up. I also react to my estradiol patch by getting completely wired, as in more awake than awake, and cannot sleep while on it.