Due to the shortages I kept getting estradot substituted for other products and found that I absorbed estraderm much more evenly. I liked the smaller size of the estradot, but for me that was the only advantage. Estraderm are big and not the nicest texture (a bit crinkly) and I hated them at first as a result, but I don't get any skin irritation and also feel on more of an even keel. The GP was convinced I shouldn't notice any difference (75mcg is 75mcg), but I'm sure there is. Good luck finding the product that works best for you.