Hello again, I took 2 fluconazole tablets x 2 prescriptions four tablets in total. One canesten pessary and external canesten cream. Each time swab, which was sent away to be cultured came back heavy yeast. The lady Doctor asked for the strain of yeast to be identified, but the lab never did this. I have only taken one of my 12 fluconazole tablets second one to be taken in the morning. I also was prescribed a 500mg canesten pessary again. The first canesten pessary didn’t dissolve properly due I guess to being so dry. Since using estriol internally the second pessary did dissolve. So happy about that. Like you I am crossing everything this latest treatment works. My pain, rather like a nagging toothache in the vagina, is intermittent and I have had three relatively better days. Fingers crossed the thrush is subsiding. I don’t itch, neither do I have the curdy discharge. Guess my pain is from the yeast infection and lack of Oestrogen. Lady doctor who did my last swab and pelvic exam said to use the estriol cream at least 4/5 times a week for a while, until I get things under control. It’s so good that we have this site and the very knowledgeable ladies to support each other. Hope you have a better day.