I was on everol 100 patch for about 4 years but started having a reaction to the patch … so now I’m on sandrena gel 2x sachets per day 2x 1.mg) with. 1 x utrogesterone tablet nightly and testerone . Take magnesium every night and still can’t sleep and have hot flushes and anxiety . I didn’t have this problem whilst on the patches. What is really bothering me is that my breasts are now tender and I seem to have some on and off pain in my left one. Also taking evening primrose and starflower daily. I am worried if I increase the Oestrogen to help with the hot flushes ….will my breast pain get worse? I thought the pain is brought on by too much oestrogen. My bloods showed my oestrogen were on the higher side but consultant said I could carry on taking the 1.0mg gel oestrogen (2sachets of sandrena) The breast pain has come about since being in the sandrena gel. To be honest since being in the gel I feel it’s not as good as the patches . Hot flushes hav reed returned and sleepless nights. Sorry for long message but thank you xx