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[Nas]

Yes March, it’s all very odd.
Personally, I think it’s a combo of mud sticks, along with so many HRT preparations to choose from, Gps lack of knowledge, fear and women not simply asking for HRT because they feel they should suck it up.

As with everything now, we have too much choice and HRT is no exception
The newer preparations are more popular than the old, that is clear.

I too would struggle with the ethics behind Premarin..but if it meant I felt more well on it, than currently, it would become a real moral dilemma!

X

[Marchlove]

Nas - this is interesting regarding Bioidentical vs Premarin

Scroll down to the section ‘Natural Claims’

X

[pepperminty]

Hi Marchlove and Nas,

I too don't like the ethics around Premarin, but I suspect that if we knew the origins and practices with most drug  manufacturing we would be horrified.
I can't think that in this day and age that the previous practices would have improved I hope.

I do think the ratio of women currently  stopping HRT due to side effects is higher . As you say Marchlove  prior  to 2002 this did not happen. I think then Premarin was the drug of choice. I think it had and still  has good results ( according to my meno specialist. Most women felt well on it. )

I feel ok ish on femosten - but felt great on premarin, which was a higher dose than my current regime , but I cant go higher on my current one due to terrible side effects.
PMxx

[Nas]

Out of interest pepperminty, what dose of Premarin did you take?

Are you on femeston conti now, or the sequi?

You are right, if we knew how many products are actually produced, we would probably never touch half of them again!

X

[Marchlove]

Whoops sorry didn’t post the link

https://en.wikipedia.org/wiki/Bioidentical_hormone_replacement_therapy

[pepperminty]

Out of interest pepperminty, what dose of Premarin did you take?

Are you on femeston conti now, or the sequi?

You are right, if we knew how many products are actually produced, we would probably never touch half of them again!

X

 Was Medium dose  Premarin, and on low dose sequi femosten  now - ached more and more stiff on this - the premarin got rid of all pain over night. Including a limp i had every morning!

PMxx

PMxx

PMXX

[pepperminty]

Whoops sorry didn’t post the link

https://en.wikipedia.org/wiki/Bioidentical_hormone_replacement_therapy

Will read link tomorrow  xx

[Nas]

Ah okay. Was it 0.625mg or 1mg Premarin? I’m contemplating it and trying to work out the dose.

X

[Floradora]

Another thing to bear in mind is that when we were prescribed things ‘years ago’ and they worked, of course we were younger, our bodies worked differently, we had different levels of our own hormones going on etc etc. so it’s probably not an ideal direct comparison. It could be that you had some of your own estrogen going on then and so the dose of Premarin was enough to make you feel fabulous. Now you will have a much lower level of naturally produced estrogen so that will be a big factor. Of course it may well be that the conjugated equine estrogen does suit you better, but it’s worth remembering that you yourself will have had a different physiological response then.
I’ve found this myself recently while taking Provera. Took it years ago (at a much higher dose) and got on great, however it doesn’t seem to agree with me so well now and I have decided to revert back to Femoston which contains dydrogesterone which now seems to be the only progesterone I can tolerate. As I’ve got older with low levels of natural estrogen and progesterone I have become much more sensitive to small changes in dosage.x

[Nas]

That’s a fair point flora and definitely worth considering.

The progesterone element seems to present the most challenges to women who wish or need to take HRT. I too like the progesterone in femeston, but wasn’t absorbing much of the Oestrogen at all.

In honesty, it’s a minefield! X

[pepperminty]

Ah okay. Was it 0.625mg or 1mg Premarin? I’m contemplating it and trying to work out the dose.

X

It was 0.62 mg - the next one up is 1.25.  The only thing i had was nausea AM, bit of boob tenderness ( that was a walk in the park compared to exhaustion, VA, anxiety etc.)
It was the progesterone part that drove me insane.

PMX

[pepperminty]

Another thing to bear in mind is that when we were prescribed things ‘years ago’ and they worked, of course we were younger, our bodies worked differently, we had different levels of our own hormones going on etc etc. so it’s probably not an ideal direct comparison. It could be that you had some of your own estrogen going on then and so the dose of Premarin was enough to make you feel fabulous. Now you will have a much lower level of naturally produced estrogen so that will be a big factor. Of course it may well be that the conjugated equine estrogen does suit you better, but it’s worth remembering that you yourself will have had a different physiological response then.
I’ve found this myself recently while taking Provera. Took it years ago (at a much higher dose) and got on great, however it doesn’t seem to agree with me so well now and I have decided to revert back to Femoston which contains dydrogesterone which now seems to be the only progesterone I can tolerate. As I’ve got older with low levels of natural estrogen and progesterone I have become much more sensitive to small changes in dosage.x

Hi,

I tried Femosten at the same time and the effects of the estrogen part were not as effective as the premarin.  But the progesterone part of the preparation in Prempac C drove me insane and made me sweat.
It is a mine field

PMxx

[Floradora]

Hi Pepperminty and Nas. Yes it does seem to be that we often end up limited in our HRT choices mainly because of the inability to tolerate progestins. I have now tried every single one that’s currently on the market either as a separate product combined with an estrogen eg Evorel patch plus Provera, or as a combined product, Femseven conti, Evorel Conti etc and others and have come to the conclusion that the dydrogesterone only one that doesn’t make me feel like crap in one way or another! Really sometimes makes me wish I’d had a hysterectomy years ago! Onwards and upwards though x

[Nas]

Totally agree Flora.
Without the progesterone to fathom out, I feel sure the HRT journey would be far easier!

I find it incredible that we spend so much time and effort in trying to feel remotely better. Yet really, it’s probably nigh on impossible to replicate the hormone levels of our youth, so we must settle for a happy medium
( somehow)

I would quite like to see where I am at in terms of symptoms, but a little scared to take the plunge and go without any form of HRT! 

Xx

[sheila99]

And wouldn't it be so much better if they all came as a standalone product so we could pick the oestrogen that suited us best too.