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[loonarider]

Hi,

As in the title. What is the risk of getting a clot with the estrogen spray Lenzetto? Can't find any info anywhere.

Also would the risk increase if you upped the dosage?

Thank you x

[Perinowpost]

As it’s transdermal it’s very low. Don’t have any facts and figures but hopefully someone else will be along who knows more x

[Joaniepat]

There is no clot risk with any of the transdermal oestrogens. You would find more details, with references, on Louise Newson's website.
JP x

[Uptick]

Hi loonarider, have you read the patient information leaflet? It mentions blood clots 21 times. Risks are always relative to each individual.

https://www.medicines.org.uk/emc/files/pil.11175.pdf

[loonarider]

Hi loonarider, have you read the patient information leaflet? It mentions blood clots 21 times. Risks are always relative to each individual.

https://www.medicines.org.uk/emc/files/pil.11175.pdf

21 times?! That's a lot! I always here that transdermal is pretty safe as far as clots go.

I suffer terribly with health anxiety. It's like part of me wants to know and part of me doesn't want to know what the risk is.

If it's very low or rare then I'm happy to continue.

[loonarider]

There is no clot risk with any of the transdermal oestrogens. You would find more details, with references, on Louise Newson's website.
JP x

I really hope so as I have health anxiety and don't want to start freaking out about an hrt that is working currently.

[loonarider]

As it’s transdermal it’s very low. Don’t have any facts and figures but hopefully someone else will be along who knows more x

Thank you peri now post x

[Postmeno3]

Aren't all these leaflets under scrutiny for accuracy? I thought this was all going to be investigated and changed. All current HRT leaflets are at least 50% about breast cancer, clots etc. It's time this was stopped if we are to accept what all recent research shows that transdermal delivery is lowest risk. The manufacturers need to stop churning out this outdated material to cover their backs.

[loonarider]

Aren't all these leaflets under scrutiny for accuracy? I thought this was all going to be investigated and changed. All current HRT leaflets are at least 50% about breast cancer, clots etc. It's time this was stopped if we are to accept what all recent research shows that transdermal delivery is lowest risk. The manufacturers need to stop churning out this outdated material to cover their backs.

Ah, it seems you're right. Outdated science.

Excerpt from PDF I downloaded from Dr. Newsons website. 

"It is important to understand that the
reported link between HRT and risk of
blood clot is based on a study that was
twenty years ago, where women were
given older types of estrogen (conjugated
equine estrogen), older synthetic
progestogens, and the estrogen was taken
in tablet form.

It is therefore sensible to ask the
questions: What risks do newer types of
estrogen have? Is there a risk difference if
the estrogen is taken by mouth or
through the skin? And is it the estrogen or
the type of progesterone that raises the
risk of clot, or is it only when a
combination of the two is used?

The more recent, good quality evidence
shows us:
There is a small risk of a blood clot
associated with oral estrogen tablets.6
High levels of estrogen in the liver (which
can occur when oral estrogen is taken)
can lead to sticky blood changes that
increase the risk of VTE.
This does not
occur with estrogen used through the skin
as a patch, gel or spray.

To understand how small this risk is,
imagine a healthy woman of 50 years of
age; she has a VTE risk of around 6 in
10,000 per year. If she took oral estrogen
tablets, this would double her risk to
around 12 in 10,000 but it’s still a small risk
overall.

The good news is that estrogen
absorbed through the skin is much
safer and does not cause sticky blood
changes and therefore does not
increase the risk of clot. Transdermal
estrogen is the type of HRT that comes in
a sticky skin patch, or a gel or spray that
you rub into your skin.

To be clear, transdermal estrogen has no extra risk and is safe to take, even
for those with a higher risk of getting a blood clot".

The last two paragraphs is what I hoped to hear.

Thanks for your input

[Uptick]

Hi loonarider, it's not outdated science. As I said before, risks are relative. Each patient is a unique person with unique medical history, genetic background, diet, physical activity, comorbidities. Generalisation can be dangerous.