Hi I’m new to this forum, but to say a big thank you to all you wonderful ladies for your honest and open posts. I am 49 and peri, periods have always been heavy, had a EA about 10 years ago, periods got closer together last few years, then I finally went a bit longer, but then my period came and with it depression and anxiety off the scale, felt like I was going mad, so scary. I r started on hrt eostrogel and urtogestan, also ads increased dose, only about 4 weeks in but still having low moods and anxiety, how long before I know if the doses are right for me?