Hello Fran, I was interested to read about your experience of Estriol cream as I've recently had a pretty bad reaction to it too... or rather I suspect I've had a bad reaction to the fillers in the cream, not the oestrogen content. ..I'm now waiting to see a gynae (referred by my nice GP) as I'm a bit in limbo as this has been going on since August and my GP wants a specialist to rule in or out lichen sclerosus (i managed to get an examination with her & she wasn't sure as its not 'presenting typically' if that is what is wrong) or if the aggravation of my vulval skin is VA or dermatitis.. or all of it! I certainly didn't have any vulval burning, redness or discomfort externally at all before using Estriol cream, just what I thought was a nasty uti (-ve on lab test)... I think I may have made things a lot worse by panicking and using a whole raft of other 'moisturising' products that have added to the irritation (yes, a bit daft, I know) I'm washing gently with water only and using dermovate on the sore area for now as directed by GP & hope the wait for a gynae appt won't be too long. How are you getting on? Did you see your GP again?