I started taking them four weeks ago, I have only good things to say. I had tried Sertraline three weeks previously which gave me really nasty side effects - strange because I had been on them before and been fine. So with the Mirtazapine, improved sleep immediately and then anxiety has gradually improved day by day. I think that they can be a problem if you struggle with weight gain, but for me an increase in appetite has been great because I tend to lose weight with anxiety so had dropped a stone before started on them. Also lots of other ADs can cause weight gain. So have managed to put on four pounds. Will obviously keep an eye on that. What dose has he given you? I am taking 15 mg. My GP says he generally finds them to be very good and well tolerated. Feel free to message me if you like.