I'm figuring out that the Vagifem may be causing a PH imbalance till it's accepted and therefore, with the urethra so nearby, peeing is causing this sense of overstimulation and sensitivity. I noted somebody saying they wash with E45 wash and rinse with tepid water after every pee and maybe I need to do that to reduce this slight inflamed state. Just water is drying seemingly? I took some D-Mannose last night and this morning which settled it all almost straight away, but don't want to overdo the D-Mannose and reduce its impact with frequency. I really want to get this figured out! Possibly some of the moisture created by the Vagifem is going to seep into the immediate external area, hence the thought that it has to be, albeit indirectly, the Vagifem? Does anyone else include a washing regime after every pee which is helpful? Thanks!!!!!!!