Hi, a very well respected menopause clinic advised me to vary insertion depth, but have a look at the current thread entitled Re: Ovestin cream started by Ann c, as Avalon has just posted a very helpful article on just this topic. Includes advice on both Estriol cream & Vagifem. Gist is that Vagifem is most effective with shallow placement & this is what I tend to do these days.
Another thought is that you may well need to increase the number of nights you use Vagifem. Many of us find we need to use it 5 nights a week long term & it's widely considered quite safe to do this. I use Estriol 0.01% cream externally in addition to Vagifem (& systemic HRT), both the topical treatments 5 nights a week.
Wx