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Author Topic: Progesterone Intolerance?  (Read 8624 times)

gillsleza

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Re: Progesterone Intolerance?
« Reply #15 on: February 18, 2021, 06:15:38 PM »

I am on two oestradot patches, allowed, and took 100mg progesterone but had a heavy bleed after 30 days. I then had continuous spotting. I asked my consultant and she said take two progesterone if another bleed happened. It did and I have been on two since 22nd Jan. I had a bleed for 8-10 days recently but still spotting and have daily period-like pains.
I am talking to my GP on Monday but am concerned as I have had to use pads or panty liners since 28th December!!  :(
I’m hoping I don’t have to have regular bleeds, as I have never heard any women on HRT have this issue. My flushes were so debilitating I would not consider stopping oestrogen EVER! As I still have a womb I know I need progesterone.
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CandaceJ

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Re: Progesterone Intolerance?
« Reply #16 on: February 22, 2021, 04:31:49 PM »

What dosage of patches are you on? And you are taking 200mg Prometrium (Utrogestan in UK) daily?

I am super confused about how much progesterone I should be taking, daily. My GP says 100mg daily. My OB/gyne says 200mg daily. I am on 100mcg Estradot. I feel better on just 100mg daily but of course don't want to risk endometrium becoming too thickened.

What to do?
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Hurdity

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Re: Progesterone Intolerance?
« Reply #17 on: March 07, 2021, 09:14:34 AM »

CandaceJ - The licensed dose is 100 mg daily (or 25 days out of 28) or 200 mg for 12 days per 28 day cycle, taken orally. This is the same irrespective of the oestrogen dose which is clearly not sensible since the amount of progesterone needed to protect the womb is dependent on the oestrogen dose. This dose may seem to be too much for women on very low oestrogen doses and insufficient on very high doses.

The dose is right if it is sufficient to prevent breakthrough bleeding in post-menopausal women on a continuous dose ( provided no womb pathology etc) ie keeps the lining thin but not overthin.

Only scans will tell you what is right for you if you are having unscheduled bleeding. You doc must have a reason for suggesting a higher dose. Maybe because you are on a higher oestrogen dose and have experienced breakthrough bleeding? Maybe a scan has shown thickened lining?

Taken vaginally it is more effective in protecting the endometrium, so some docs prescribe a lower dose if taken this way although unfortunately this is off-licence.

Hurdity x
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Sarahjane

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Re: Progesterone Intolerance?
« Reply #18 on: March 12, 2021, 01:44:29 PM »


From what I understand Dr Newson recommends 100 ustrogestan/Prometrium orally per day, OR
100 ustr/prom vaginally every second day (although I have heard in Australia some have been lowered to Monday, Wednesday and Fridays of each week)
OR 200 on day 15 to 28 of each month orally. or half that vaginally.
Vaginally required half the amount taken orally.
When I enquired about the amount of progesterone for the different amounts of estrogen, I was old this amount is suitable for all amount of Estrogen being used. 50/75/100 etc.

But I have yet to find a perfect level and feel confused most of the time about returning symptoms
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