Hi there, I have been taking Estradot Patches 37.5mg for the last 3 months, before I started taking it my mood was good, I take antidepressants outside of the perimenopause for Anxiety, but since starting on the HRT my mood has gone downhill, feeling depressed and the anxiety has gotten really bad in the last week. I am wondering would the HRT cause Anxiety/Depression? The hot flushes, night sweats are gone but I find the low mood difficult to deal with. I would like some advise from anyone who has had worsening mental health issue from taking HRT. Thanks, Joanne