Tnx 4 the update Bring me Sunshine. Certainly Dr Dalton did a lot of work in the 1970s/80s/90s about premenstrual depression and how it affects women to the point of killing people. So hormones can have a devastating impact during The Change. I do believe that ADs can help ease those symptoms whilst HRT is 'sorted' considering how long it might take to find a balance. I was already on ADs and anti-anxiety meds when I went into peri and I think that helped me a lot.
Many medications can have the opposite effect as to what they were designed for, a friend goes hyper on betablockas for example.
As with everything, we are all so different. That's why it's Trial and Error and oh, at times, so hard.