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Author Topic: Vaccines under development against novel coronavirus and Covid-19  (Read 1904 times)

Hurdity

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If anyone wants to read a bit more about vaccines in development there is some interesting information here (the website I linked to earlier on the other threads) about how vaccines are developed and the stages involved before they can be used:

https://coronavirusexplained.ukri.org/en/section/vaccination-diagnosis-treatment/

That is the easiest to read and understand explanation in layperson's terms. This same organisation also lists the details of the vaccines being developed in UK:

https://www.ukri.org/news/covid-19-vaccine-therapy-research-boosted-by-six-new-projects-in-rapid-response/

"COVID-19 vaccine & therapy research boosted by six new projects in rapid response

23/03/2020

Six new studies into the novel coronavirus have been funded by the UK government, including testing a vaccine, developing therapies and improving understanding of how to treat COVID-19. 

This first round of projects receive ?10.5 million as part of the ?20 million rapid research response funded by UK Research and Innovation (UKRI), and by the Department of Health and Social Care through the National Institute for Health Research.   

A promising new vaccine that has been developed by UK researchers will be supported through pre-clinical and clinical trials to determine if it is safe and effective. The researchers will also be funded to develop manufacturing processes for producing the vaccines at a million-dose scale, so that - if clinical trials are successful - a vaccine could be made available to high-risk groups as quickly as possible. 

Patients hospitalised in the NHS with COVID-19 are taking part in a new clinical trial to test therapies, starting with lopinavir-ritonavir and low-dose corticosteroids.

Other projects will develop new therapeutic antibodies and screen hundreds of existing drugs in the lab to find ones that show promise against the novel coronavirus.

Another project will collect data on COVID-19 NHS patients to answer many urgent questions ? such as what treatments work best? how is the disease transmitted? And, why are some people at higher risk of severe illness? ? to inform efforts to control the outbreak and improve treatment for patients in real time.

The research supports the UK government's efforts to save lives, protect the vulnerable and support the NHS so it can help those who need it the most. It builds on the UK's world class expertise and capability in global heath and infectious disease that has already shaped our understanding of the pandemic and is informing measures to tackle it."


Also Wikipedia has a very informative uptodate page.

https://en.wikipedia.org/wiki/COVID-19_vaccine

Here is the introduction:

"A COVID-19 vaccine is a hypothetical vaccine against coronavirus disease 2019 (COVID-19). Although no vaccine has completed clinical trials, there are multiple attempts in progress to develop such a vaccine. In late February 2020, the World Health Organization (WHO) said it did not expect a vaccine against SARS-CoV-2, the causative virus, to become available in less than 18 months.[1] The Coalition for Epidemic Preparedness Innovations (CEPI) ? which is organizing a US$2 billion worldwide fund for rapid investment and development of vaccine candidates[2] ? indicated in April that a vaccine may be available under emergency use protocols by early 2021.[3]

By April 2020, 115 vaccine candidates were in development, with five organizations having initiated Phase I safety studies in human subjects
".[3][4]

In addition the World Health Organisation has produced a list of  potential types of vaccine in development world wide:

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus-landscape-ncov.pdf?ua=1

There is also a long list of research projects and trials going on:

https://www.who.int/blueprint/priority-diseases/key-action/novel-coronavirus/en/

I mean you could spend hours if you wanted to!

Needless to say I haven't read them but have researched the most up-to-date information that anyone with a scientific bent who would like to look into it a bit more deeply  ::)!

Hurdity x
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Hurdity

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Re: Vaccines under development against novel coronavirus and Covid-19
« Reply #1 on: April 24, 2020, 07:03:50 PM »

Here are links to easily understood accounts of the latest developments which have been reported in the news recently

Firstly the idea of convalescent plasma, not a vaccine as such but takes advantage of anti-bodies produced in the persomn who had the infection and transferring them to sick patients:

https://coronavirusexplained.ukri.org/en/article/vdt0007/

News article about the vaccine trial which started yesterday by the University of Oxford team:

http://www.ox.ac.uk/news/2020-04-23-oxford-covid-19-vaccine-begins-human-trial-stage

More information:

https://covid19vaccinetrial.co.uk/
https://covid19vaccinetrial.co.uk/about

Hurdity x
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