I'm using estring and estrace (generic estradiol cream) for VA, plus systemic estrogen via Duavee as well as a little testosterone. The Estring is genius and works. I put it in every 3 months and really dont know it's there (I'm not at all squeamish though, but find it really easy to insert and remove). I put the estradiol on the outside, just a bit as per my doc. I can tell the estring is coming to the end of its 3 months when I get more sore etc just for no reason, not even sex. Tbh, some level of systemic estrogen may be needed to really keep things going. The external extrogen products have not been shown to add to systemic estrogen levels or cancer risk, in fact they are often allowed for breast cancer patients with e+ cancer. They do help. But sometimes it takes all fronts to improve the most.