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Menopause Matters magazine ISSUE 58 out now. (December 2019)

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Author Topic: Human scalp hair: Modulation by various factors and hormones  (Read 336 times)

BeaR

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Human scalp hair: Modulation by various factors and hormones
« on: December 02, 2019, 02:43:19 PM »

Hi girls, (special hello to Sammiejane)

This is a recent article on the interaction between human scalp hair and hormones, particularly oestrogens.

Human scalp hair: Modulation by various factors and hormones, do estrogens inhibit or stimulate A perplexing perspective
Edwin D. Lephart PhD
First published: 15 February 2019 https://doi.org/10.1111/jocd.12888

Sammie, if you'd like to read the article, I have a 48-hour access and will be glad to send you the important bits.

BeaR.
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Sammiejane

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #1 on: December 02, 2019, 03:34:38 PM »

hi bear

loverly to hear from you yes please that would be excellent !

you could email me if it’s easier

thank you
« Last Edit: December 02, 2019, 09:08:47 PM by Sammiejane »
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Birdy

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #2 on: December 02, 2019, 04:01:30 PM »

Also Sammie, google saw palmetto to prevent DHT conversion from testosterone  and look up DIM which apparently prevents oestrogen converting to estrone.
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Turkish delight

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #3 on: December 02, 2019, 04:03:25 PM »

Hia BeaR

The link wouldn't load for me :(

Could you or SJ please put the bullet points in this thread as my scalp is really interested in what Edwin has to say ;)

TD
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BeaR

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #4 on: December 02, 2019, 05:20:47 PM »

Hi girls,

Sammie, I have sent you the article. I think you should delete or edit your post so your email address won't be disclosed to the world wide web!  ;) I had sent you a PM, but I guess you haven't read it.

Turkish delight, try this other link https://www.ncbi.nlm.nih.gov/pubmed/30770632 Anyway, it's just an abstract.

I will post the bullet points later on, I must dash!

BeaR.
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Birdy

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #5 on: December 02, 2019, 05:29:05 PM »

Thanks BeaR
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Alicess

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #6 on: December 02, 2019, 08:05:21 PM »

I'm very interested too. Thanks, BeaR
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BeaR

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #7 on: December 05, 2019, 01:01:57 AM »

Hi girls,

You're welcome! I'm still reading the important articles quoted in this mini review, in the meantime I came across another recent article (full text available) that is very interesting and easy to understand.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419033/

My life is a bit chaotic ::) atm but I promise I will come back with some interesting thoughts on this subject.

BeaR.
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Hurdity

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #8 on: December 05, 2019, 08:55:59 AM »

Thanks bear -  being naturally curious, the first study I got a copy from the author through an organisation I belong to. For anyone interested it is VERY technical! Also showing that some of the apparently conflicting results were due to the use of rat and mouse models and that you can't extrapolate these findings to humans. I can't pretend to follow it all as you would need to be a specialist really and it is very complex - and would be very time-consuming! However here is the conclusion:

"The topics in this brief summary cover the known and potentially knowable components of how 17β‐estradiol influences human scalp hair growth. Of course, the differences and similarities between human and murine hair biology remain and it would be much easier to demonstrate a clear‐cut role of 17β‐estradiol in human hair
growth; unfortunately, this is still not possible due to the complex number of interactions in the cellular/molecular signaling cascades that are involved in the cycling and growth of human hair."

It is clear there is still much to understand and although very interesting from a biological point of view will not actually enable anyone to decide what is the cause of their particular hair loss - and like other members have said on other threads - there are so many factors and interactions that HRT per se cannot be blamed, but will depend on a woman's particular circumstances - very difficult and frustrating!

However one thing did stand out and that was the role of cortisol - which the study said was incorporated into the hair follicle and that some studies show that cortisol inhibits hair growth. As we know cortisol is a stress hormone and this does stand to reason - we've heard anecdotally of people who's hair has "fallen out with shock". Therefore just knowing this - it seems to me one positive thing that anyone could do irrespective of whatever else is going on - is to try to stop worrying and reduce stress - so that excess cortisol can be lowered? Probably too simplistic maybe this would help? At least it would have other beneficial effects on your health - reducing stress and worry....

I would suggest bear that the second reference is also very technical and not easy to understand unless you have knowledge and understanding of the biological processes - it is not a "lay" paper!!

It does go through drug treatment of certain types of hair loss. In fact it reminds me I started looking into this a while ago and dug out some refs and articles on hair loss. The treatment recommended for women ( Finasteride) is only licesned at low dose for younger men with the early stages of hair loss (androgenetic alopecia), and at higher doses for prostate problems!

If you have any interesting thoughts that will help women who are suffering from this problem to overcome it, this would be very useful.

Hurdity x
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jaycee

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #9 on: December 05, 2019, 10:08:43 AM »

I am very interested, as i have been suffering hair loss for the last year at least
The dermatologist i saw put it down to stress, but last a lot in a very short ime,
Lost even  more when put on Evoral Conti, so could be a mix of stress and hormones
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Lola50

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #10 on: December 05, 2019, 10:09:06 AM »

That's great, Hurdity. Thank you for taking the time with this. I was curious, too.

I answered Sammiejane regarding her HRT difficulties and the role that smoking plays in another thread. (And her long saga with her hair loss).

Interestingly, cortisol levels are higher in smokers, so I think she really should look at this aa a contributing factor to her issues.
https://www.ncbi.nlm.nih.gov/m/pubmed/16337291/

As you say, it's complex and we can't lay the blame on everything on HRT, dose type or lack of .

And of course as we get older we are less tolerant of many things including smoking and drinking, and potentially even certain types of foods and medicatoons especially during and after menopause.
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BeaR

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #11 on: December 05, 2019, 10:53:02 AM »

Hi girls,

Jaycee, I'm sorry you're also struggling with this, it's very distressing, My scalp hair loss is mainly in the vertex, but I had been on HRT for only 3 months. You're absolutely right it's a mix of stress, hormones and other things as well that I will be discussing soon. Lots of love.

As I said before I don't have time to discuss the articles now, but I will certainly do it later on.

Regarding smoking, I have been chatting with Sammie by email and this topic has been extensively covered  ;)

BeaR.
« Last Edit: December 05, 2019, 12:01:28 PM by BeaR »
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Lola50

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #12 on: December 05, 2019, 12:37:08 PM »

Ah, good to know BeaR re: the smoking!👍💜
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Hurdity

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #13 on: December 05, 2019, 03:12:44 PM »

Hi girls,

Jaycee, I'm sorry you're also struggling with this, it's very distressing, My scalp hair loss is mainly in the vertex, but I had been on HRT for only 3 months. You're absolutely right it's a mix of stress, hormones and other things as well that I will be discussing soon. Lots of love.

As I said before I don't have time to discuss the articles now, but I will certainly do it later on.

Regarding smoking, I have been chatting with Sammie by email and this topic has been extensively covered  ;)

BeaR.

May I respectfully suggest that any discussion about private messages or conversations is kept private. It is (probably unwritten!) protocol not to mention whether you're in touch with anyone by pm or e-mail because this is a private matter - usually what members say if they refer to any such exchange  is "I've sent you a pm" or just send it! This is a public open forum and as such all the information on here is for public consumption and for all members to post. It gets a bit awkward referring to private convos (especially with a knowing wink) on an open thread. Sometimes members might not want others to know if they have been in touch with other members and who they are and the content of their convos. So - the smoking and hair loss issues are of interest to all. I only mention this bear because you also referred to a private convo on another thread a couple of weeks ago and I brought it up then - so just thought I would mention it in a bit more detail!

If anyone thinks this is too outspoken - well I certainly would not want the content of any of my pms or e-mail discussions aired on the open forum, nor it be known whom I was in contact with - and I am sure there are others who might think the same and perhpas be worried about sending pms etc - so just putting it out there. ::)

Happy days :)

Hurdity x
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Lola50

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Re: Human scalp hair: Modulation by various factors and hormones
« Reply #14 on: December 05, 2019, 03:58:21 PM »

I agree with that totally, Hurdity. 💜
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