Hi ladies...I had a hysterectomy about 16 yrs ago, I'm now 56, kept my ovaries and struggled for years with night sweats and low mood but kept being told I wasn't peri or menopausal. I have been on Estradot 100micrograms/24hr patches for about 4 years now. I have also been on anti-depressants for most of my adult life. I did come off them slowly over a 12 month period but within 3 months of stopping them the symptoms came back so I started back on medication, Mirtazapine 45mg at night. I don't have an issue with anti-depressants but between them and the HRT I don't feel as though they're really working. I did book a medication review appointment with my GP to discuss my meds and he basically said it's a difficult balance to get right as you would need to come off the HRT slowly and then introduce another one and finding the one that's right for you can take time. I'm scared of going back to how I was feeling before the HRT but how would I know when to start coming off it? I feel anxious most of the time, have palpitations and feel low and tearful....I think the meds numb you also. I have so much to be thankful for...beautiful grandson, daughter, husband, job etc etc but I don't feel any joy or happiness. It's so isolating as it's difficult to put into words how you're feeling. Should I try a meds review again and discuss maybe coming off the HRT? Is there any point being on anti-depressants and HRT if I'm still feeling this low?