well, i am on estrogel 2-3 pumps a day with utrogestan and i noticed that it's not as effective as when i started four years ago. I started on 1 pump, and two years later i increased the dosage to 2 pumps. Now i have to use 3 to get the same effect. A lower dosage immediately brings on hot flushes, insomnia and anxiety. When i started i had been post-menopausal for a year, so maybe my body was still producing some estrogen, 4 years later i need more estrogen just to feel the same. It makes sense, because our bodies age and maybe our estrogen receptors become lazier or slower, possibly building a tolerance.
