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[Dipo]

Thank you for your responses, roseandthorn and Hurdity. I don't want to try the coil as I've had a couple of friends with very unpleasant experience using it. I did use Utrogestan vaginally for a while but my doctor is very cautious and would not prescribe me the 100mg capsules for this, only the 200. Of course this made things even worse, since as you say even more gets to the uterus this way. My doctor was only willing to prescribe Utrogestan at all if I was also being checked annually by the Menopause Clinic specialist, but due to cutbacks those consultations were stopped. I would be very interested in the studies you refer to so yes, if you have the time to post them that would be a real help.
Many thanks.

PS It took me a lot of searching to find these responses - is there a quick way to find messages on here, like a facebook or email update?

[Moanybreeks]

Received a reply from Theramex this am stating the same adhesive issues and a new expected date for January 2020.  The usual referral to GP for alternative HRT.  I am 8 weeks into Femoston 0.5mg and have had 3 bleeds already.  Not keen on oral HRT but have limited choice. Perservering whilst waiting for Femseven but that time line seems infinite

[roseandthorn]

Theramex haven't even bothered to reply to me asking for an update. I am having the Mirena fitted next week. I miss how well I felt on FemSeven Conti.

[Moanybreeks]

roseandthorn. Me too, I had the least side effects with it, although sticking was an issue, especially after a swim..  They sent me a pre-formatted reply with my name added..

[roseandthorn]

They finally replied this afternoon with the generic attachment, having changed the target date to "early 2020." I don't really believe that it'll appear again on the market or that Theramex have any great interest in the wellbeing of the women who were on the patches. I generally didn't have problems with the patches sticking but if one did dislodge, I just moistened it a bit and it stuck back on. My Mirena is being fitted next Tuesday.

[Jo24]

Me again !
I bear news regarding the F7 fiasco 🙄
The latest communication I have received from Thera (after much pestering) is that FemSeven Conti has not been discontinued, they anticipate it will be re-marketed in Spring 2020; someone is still faffing about with their 'chemistry set' to get the adhesive sorted .... so! panic over in one respect.

On a personal note, I am using Evorel Conti as an alternative, and other than a lot of headaches, I have noticed no other significant difference in how I feel; my biggest concern was its potential to alter mood (I have developed Meno anxiety), but all is fine in that respect.
I did have other options to try, eg Oest patch + oral Prog, etc, but the convenience of a single patch (for me) was the primary reason for trying the Ev first.

[roseandthorn]

That's good, Jo24.... About Evorol suiting you. I think Theramex might find that by the time they get FemSeven Conti back on the market, everyone has found alternatives which work for them and don't need it go back on it.

On a personal update note...have had high drama over the last 48 hours. Catastrophic bleeding whilst still on FemSeven 50 and utrogestan.   Eventually resulted in the five hour stint from hell in A&E.....musings about hysteroscopy looking for endometrial cancer, High BP and all sorts of nasty stuff. Given Tranexamic acid to stem the bleeding and sent to arrange referral to Gyne for said hysteroscopy. Saw private meno specialist instead as had an appointment notionally to fit the Mirena but she was reassuring and referred me for a scan instead saying her bet was either on a fibroid or polyp. Had the scan today with brilliant Gyne Radiologist who gave me the all clear , I do have a fibroid but he said the bleed was actually due to a thickened endometrium (from being on the Conti patches for so long) which has now shed precipitated by the change in HRT. Am now trialling Femoston Conti 1/5 ....so far so good. 😰

[Hurdity]

Bump for bear
...and femseven users!

This is the thread I was referring to. Start from the beginning and all will be revealed! Well some of it anyway!

Hurdity x

[bear]

Thank you, I wonder what the ladies who have posted on this thread are doing on he new forced regimen?

One link posted by Connolly is very interesting, but I couldn't access the MIMS page (for fully registered users only, whatever that is) of 'Deleted products on the 7 November 2018'. https://www.mims.co.uk/deleted-products-2018/article/1491156

According to the link posted, FemSeven Conti and Sequi were listed as 'Discontinued' by a NHS hospital?

BeaR.

[bear]

Hi FemSeven users,

This patent might explain why it's taking so long for Theramex to sort out the adhesive issue. Noven Pharmaceuticals, the real manufacturer of Estradot (Novartis is just a licensee in Europe) has a new patent of a transdermal patch system, including one containing estradiol and levonorgestrel https://patents.google.com/patent/EP3253840A1/en?q=levonorgestrel&assignee=noven&oq=noven+levonorgestrel
https://patents.google.com/patent/WO2017004507A1/en?q=levonorgestrel&assignee=noven&oq=noven+levonorgestrel

Noven currently has three products marketed in the US, Minivelle (estradiol patch), Combipatch (estradiol + norethindrone) and a generic estradiol patch (I think it's the first generic in the world). http://www.noven.com/womens-health.php

I guess Theramex is waiting to see if it will be profitable to compete with them in Europe. If that is the case, maybe there will be another option available soon.

BeaR.

[KiltedCupid]

Hi FemSeven users,

This patent might explain why it's taking so long for Theramex to sort out the adhesive issue. Noven Pharmaceuticals, the real manufacturer of Estradot (Novartis is just a licensee in Europe) has a new patent of a transdermal patch system, including one containing estradiol and levonorgestrel https://patents.google.com/patent/EP3253840A1/en?q=levonorgestrel&assignee=noven&oq=noven+levonorgestrel
https://patents.google.com/patent/WO2017004507A1/en?q=levonorgestrel&assignee=noven&oq=noven+levonorgestrel

Noven currently has three products marketed in the US, Minivelle (estradiol patch), Combipatch (estradiol + norethindrone) and a generic estradiol patch (I think it's the first generic in the world). http://www.noven.com/womens-health.php

I guess Theramex is waiting to see if it will be profitable to compete with them in Europe. If that is the case, maybe there will be another option available soon.

BeaR.

Thanks for that BeaR - Fem7 is the only prog I can JUST tolerate and may be my salvation from a hyster. At least this proves there's no jiggery pokery with stockpiling or distribution chains, it's just a simple product reformulation.

[Hurdity]

Hi FemSeven users,

This patent might explain why it's taking so long for Theramex to sort out the adhesive issue. Noven Pharmaceuticals, the real manufacturer of Estradot (Novartis is just a licensee in Europe) has a new patent of a transdermal patch system, including one containing estradiol and levonorgestrel https://patents.google.com/patent/EP3253840A1/en?q=levonorgestrel&assignee=noven&oq=noven+levonorgestrel
https://patents.google.com/patent/WO2017004507A1/en?q=levonorgestrel&assignee=noven&oq=noven+levonorgestrel

Noven currently has three products marketed in the US, Minivelle (estradiol patch), Combipatch (estradiol + norethindrone) and a generic estradiol patch (I think it's the first generic in the world). http://www.noven.com/womens-health.php

I guess Theramex is waiting to see if it will be profitable to compete with them in Europe. If that is the case, maybe there will be another option available soon.

BeaR.

If you look closely at the second ref of the two about patents (the first one is not about the hormones themselves) it is not an estradiol/levo patch that is being patented but ethinyl estradiol with levo and I presume it is intended as a transdermal alternative to the CCP containing the same hormones ie as a contraceptive patch if I've read correctly. As such, although interesting to CCP users it is not an alternative or competitor to the HRT Femseven patches which contain the bio-identical estradiol.

Re your speculation re the products and Theramex, unless you have inside info on this company - even if a competitor (the one you mention Noven) were developing a similar product, I can't see that a company (Theramex - who is reformulating their own product) is going to wait years to see how a competitor does.

Also looks like Noven only prdocued products for US which is not relevant here eg they produce and estradiol/norethisterone (well similar prog) type patch - similar to Evorel produced by Janseen. However if they were to produce a new HRT type that wasn't already available here I can imagine it might be considered for licensing.

However it is of course very frustrating for Femseven users not to have a date given but I can understand that retesting of the patch (with its new adhesive) is necessary (including pharmacokinetic info - ie how it absorbs into the body and the concentration of the hormones obtained, and how long they remain/how they break down over time) before re-release onto the market.

Hurdity x

[Hurdity]

Thanks for that BeaR - Fem7 is the only prog I can JUST tolerate and may be my salvation from a hyster. At least this proves there's no jiggery pokery with stockpiling or distribution chains, it's just a simple product reformulation.

KiltedCupid - bear's post does not prove this at all as explained in my previous post. However we do know this anyway and have done for some time ie that in the case of Femseven it is a case of product reformulation. If you read from the start of this thread you will see that several of us wrote to Theramex and posted their response. I posted mine in detail (verbatim) - so that is what we have to go on. Several members have written since but I gather there is no further information about dates as yet. I can understand how frustrating this must be for you and all the others who can tolerate this prog!! Hopefuly it won't be too long.....

Hurdity x

[atalanta]

Femseven was good for me for 2 years before it was suddenly withdrawn from the market. I've been using Evorel patches since June and they seem to be ok so far.
You change the patch twice as week instead of once and occasionally I've forgotten, but so far so good. I've been pleasantly surprised. The other thing to say is that a sensitivity to a certain prog taken orally (i.e in pill form) doesn't mean there is always the same sensitivity to the same prog in a patch. It can be worth trying.   

[KiltedCupid]

Femseven was good for me for 2 years before it was suddenly withdrawn from the market. I've been using Evorel patches since June and they seem to be ok so far.
You change the patch twice as week instead of once and occasionally I've forgotten, but so far so good. I've been pleasantly surprised. The other thing to say is that a sensitivity to a certain prog taken orally (i.e in pill form) doesn't mean there is always the same sensitivity to the same prog in a patch. It can be worth trying.   

Thank you Atlanta. I've used Evorel Sequi and conti in the past and I'm afraid the norethisterone made me very unwell, although I absolutely agree there's a huge difference between oral and transdermal. I'm fortunate to (probably) have enough fem7 to limp through on a long cycle sequi until early 2020, but not much longer. Glad they're working for you.