I had period type cramps in the first few months on vagifem, don't worry it will settle, its a sign things are coming back to life. I also had sore breasts, leg cramps and anxiety about everything. Couldn't believe I had atrophy (never heard of it) and took a while to come to terms with the fact it was for life. My atrophy came on very suddenly and became severe very quickly also causing a prolapse, so it took a while to reverse the damage. I was also on steroid creams to help heal the raw skin. That was 4 years ago, I'm 62 now and still working fulltime and leading a normal life and managing my atrophy. I also recommend you ask your doctor for Ovestin to use on the outside, i started using this a year ago as well as vagifem and it has made a vast improvement for me.