I messed around for a couple of years on two, three a week, then every other day, it didn't work for me and I struggled all that time. Now I just use everyday, morning or night, makes no difference whichever you prefer. I also use Ovestin on the outside daily too, but use this at night so it has chance to absorb better as not going to the loo all day. Use the YES water based moiturisor, this is organic and don't sting at all and I am super sensitive. You have to keep this up all the time but it will get better and then becomes routine.