NOMoreHeroics, is any one actually monitoring your situation? If you have menopause related mood problems you need to get your estrogen level way up before you'll feel any difference in depression, it's a very different ball game from just alleviating hot flushes etc. which takes a relatively small amount of estrogen. Progesterone can be calming in some women but in others it's a complete nightmare, causing a huge array of negative symptoms. Then there's also testosterone to consider. You can't hope to sort this out for yourself without expert help, and in my experience that means finding a menopause expert, either an NHS clinic or private if necessary, because your average GP doesn't have a clue about this stuff. Don't leap to ADs as the answer, they're not an appropriate treatment if your mood problems are hormone related.