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Hi CazIf you look in the Green Menu under "HRT Preparations" and "Estrogens", you'll see that 0.625 Premarin is listed as "Medium dose" whereas 1mg Zumeron is listed as "Low dose" so you are actually changing to a stronger HRT. If you find that it doesn't suit you (though it might well do ) you could try a different one from the "Medium dose" list.Bette x